3INM

Crystal structure of human cytosolic NADP(+)-dependent isocitrate dehydrogenase R132H mutant in complex with NADPH, ALPHA-KETOGLUTARATE and CALCIUM(2+)

Summary for 3INM

Entry DOI	10.2210/pdb3inm/pdb
Descriptor	Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-OXOGLUTARIC ACID, ... (7 entities in total)
Functional Keywords	rossmann fold, nadp, ketoglutarate, quaternary complex, oxidoreductase, glyoxylate bypass, magnesium, manganese, metal-binding, peroxisome, tricarboxylic acid cycle
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : O75874
Total number of polymer chains	3
Total formula weight	147547.10
Authors	Fontano, E.,Brown, R.S.,Suto, R.K.,Bhyravbhatla, B. (deposition date: 2009-08-12, release date: 2009-11-24, Last modification date: 2023-09-06)
Primary citation	Dang, L.,White, D.W.,Gross, S.,Bennett, B.D.,Bittinger, M.A.,Driggers, E.M.,Fantin, V.R.,Jang, H.G.,Jin, S.,Keenan, M.C.,Marks, K.M.,Prins, R.M.,Ward, P.S.,Yen, K.E.,Liau, L.M.,Rabinowitz, J.D.,Cantley, L.C.,Thompson, C.B.,Vander Heiden, M.G.,Su, S.M. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature, 462:739-744, 2009 Cited by PubMed: 19935646 DOI: 10.1038/nature08617 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation