2QFX

Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADPH, a-ketoglutarate and Ca(2+)

Summary for 2QFX

Entry DOI	10.2210/pdb2qfx/pdb
Related	2QFV 2QFW 2QFY
Descriptor	Isocitrate dehydrogenase [NADP], CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	rossmann fold, oxidoreductase
Biological source	Saccharomyces cerevisiae (yeast)
Cellular location	Mitochondrion: P21954
Total number of polymer chains	6
Total formula weight	294448.10
Authors	Peng, Y.J.,Ding, J.P. (deposition date: 2007-06-28, release date: 2008-07-01, Last modification date: 2023-11-15)
Primary citation	Peng, Y.J.,Zhong, C.,Huang, W.,Ding, J.P. Structural studies of Saccharomyces cerevesiae mitochondrial NADP-dependent isocitrate dehydrogenase in different enzymatic states reveal substantial conformational changes during the catalytic reaction Protein Sci., 17:1542-1554, 2008 Cited by PubMed: 18552125 DOI: 10.1110/ps.035675.108 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation