2QFX

Crystal structure of Saccharomyces cerevesiae mitochondrial NADP(+)-dependent isocitrate dehydrogenase in complex with NADPH, a-ketoglutarate and Ca(2+)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Isocitrate dehydrogenase [NADP]	polymer	427	48143.1	6	UniProt (P21954) Pfam (PF00180)	Saccharomyces cerevisiae (yeast)	Idp1p, Oxalosuccinate decarboxylase, IDH, NADP+, -specific ICDH, IDP
2	G, J, M, P, S... (A, B, C, D, E...)	CALCIUM ION	non-polymer		40.1	6	Chemie (CA)
3	H, K, N, Q, T... (A, B, C, D, E...)	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	6	Chemie (NDP)
4	I, L, O, R, U... (A, B, C, D, E...)	2-OXOGLUTARIC ACID	non-polymer		146.1	6	Chemie (AKG)
5	AA, BA, CA, DA, Y... (C, D, E, F, A...)	water	water		18.0	227	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 1 - 413 (UniProt: P21954)

PDB	External Database	Details
Met -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
Ala -6	-	expression tag
Met -5	-	expression tag
Gly -4	-	expression tag
Ile -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	288858.5
Non-Polymers*	Number of molecules	18
	Total formula weight	5589.6
All*	Total formula weight	294448.1

*Water molecules are not included.