1NA5
 
 | | INTEGRIN ALPHA M I DOMAIN | | Descriptor: | Integrin alpha-M | | Authors: | McCleverty, C.J, Liddington, R.C. | | Deposit date: | 2002-11-26 | | Release date: | 2003-05-20 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies
Biochem.J., 372, 2003
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1IDN
 | | MAC-1 I DOMAIN METAL FREE | | Descriptor: | CD11B | | Authors: | Baldwin, E.T. | | Deposit date: | 1998-06-10 | | Release date: | 1998-11-04 | | Last modified: | 2019-07-17 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Cation binding to the integrin CD11b I domain and activation model assessment
Structure, 6, 1998
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1IDO
 | | I-DOMAIN FROM INTEGRIN CR3, MG2+ BOUND | | Descriptor: | INTEGRIN, MAGNESIUM ION | | Authors: | Lee, J.-O, Liddington, R. | | Deposit date: | 1996-03-12 | | Release date: | 1996-08-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Crystal structure of the A domain from the alpha subunit of integrin CR3 (CD11b/CD18).
Cell(Cambridge,Mass.), 80, 1995
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1IJB
 | | The von Willebrand Factor mutant (I546V) A1 domain | | Descriptor: | von Willebrand factor | | Authors: | Fukuda, K, Doggett, T.A, Bankston, L.A, Cruz, M.A, Diacovo, T.G, Liddington, R.C. | | Deposit date: | 2001-04-25 | | Release date: | 2002-07-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural basis of von Willebrand factor activation by the snake toxin botrocetin.
Structure, 10, 2002
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1JLM
 | | I-DOMAIN FROM INTEGRIN CR3, MN2+ BOUND | | Descriptor: | INTEGRIN, MANGANESE (II) ION | | Authors: | Lee, J.-O, Liddington, R. | | Deposit date: | 1996-04-09 | | Release date: | 1997-01-11 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Two conformations of the integrin A-domain (I-domain): a pathway for activation?
Structure, 3, 1995
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1Q0P
 | | A domain of Factor B | | Descriptor: | Complement factor B, MANGANESE (II) ION | | Authors: | Bhattacharya, A.A, Liddington, R.C. | | Deposit date: | 2003-07-17 | | Release date: | 2004-03-30 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal Structure of the A Domain from Complement Factor B Reveals an Integrin-like Open Conformation.
STRUCTURE, 12, 2004
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1PT6
 | | I domain from human integrin alpha1-beta1 | | Descriptor: | GLYCEROL, Integrin alpha-1, MAGNESIUM ION | | Authors: | Nymalm, Y, Puranen, J.S, Nyholm, T.K.M, Kapyla, J, Kidron, H, Pentikainen, O, Airenne, T.T, Heino, J, Slotte, J.P, Johnson, M.S, Salminen, T.A. | | Deposit date: | 2003-06-23 | | Release date: | 2004-04-13 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.87 Å) | | Cite: | Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1.
J.Biol.Chem., 279, 2004
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1QCY
 | | THE CRYSTAL STRUCTURE OF THE I-DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1 | | Descriptor: | I-DOMAIN OF INTEGRIN ALPHA1BETA1, MAGNESIUM ION | | Authors: | Kankare, J.A, Salminen, T.A, Nymalm, Y, Kaepylae, J, Heino, J, Johnson, M.S. | | Deposit date: | 1999-05-12 | | Release date: | 2003-09-02 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Jararhagin-derived RKKH Peptides Induce Structural Changes in a1I Domain of Human Integrin a1b1
J.Biol.Chem., 279, 2004
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1QC5
 | | I Domain from Integrin Alpha1-Beta1 | | Descriptor: | MAGNESIUM ION, PROTEIN (ALPHA1 BETA1 INTEGRIN) | | Authors: | Deivanayagam, C.C, Narayana, S.V. | | Deposit date: | 1999-05-17 | | Release date: | 2000-05-17 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Trench-shaped binding sites promote multiple classes of interactions between collagen and the adherence receptors, alpha(1)beta(1) integrin and Staphylococcus aureus cna MSCRAMM.
J.Biol.Chem., 274, 1999
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1RD4
 | | An allosteric inhibitor of LFA-1 bound to its I-domain | | Descriptor: | 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE, Integrin alpha-L | | Authors: | Crump, M.P, Ceska, T.A, Spyracopoulos, L, Henry, A, Archibald, S.C, Alexander, R, Taylor, R.J, Findlow, S.C, O'Connell, J, Robinson, M.K, Shock, A. | | Deposit date: | 2003-11-05 | | Release date: | 2004-03-30 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry
Biochemistry, 43, 2004
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1LFA
 | | CD11A I-DOMAIN WITH BOUND MN++ | | Descriptor: | CD11A, CHLORIDE ION, MANGANESE (II) ION | | Authors: | Leahy, D.J, Qu, A. | | Deposit date: | 1995-09-08 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Proc.Natl.Acad.Sci.USA, 92, 1995
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1MHP
 | | Crystal structure of a chimeric alpha1 integrin I-domain in complex with the Fab fragment of a humanized neutralizing antibody | | Descriptor: | FAB FRAGMENT, light chain, Fab fragment, ... | | Authors: | Karpusas, M, Taylor, F, Ferrant, J, Weinreb, P, Garber, E. | | Deposit date: | 2002-08-20 | | Release date: | 2003-04-15 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal Structure of the alpha 1 beta 1 Integrin I Domain in Complex with
an Antibody Fab Fragment
J.Mol.Biol., 327, 2003
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1SHT
 | | Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor | | Descriptor: | ACETATE ION, Anthrax toxin receptor 2, MAGNESIUM ION | | Authors: | Lacy, D.B, Wigelsworth, D.J, Scobie, H.M, Young, J.A.T, Collier, R.J. | | Deposit date: | 2004-02-26 | | Release date: | 2004-04-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
Proc.Natl.Acad.Sci.USA, 101, 2004
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1MJN
 | | Crystal Structure of the intermediate affinity aL I domain mutant | | Descriptor: | Integrin alpha-L, MAGNESIUM ION | | Authors: | Shimaoka, M, Xiao, T, Liu, J.H, Yang, Y.T, Dong, Y.C, Jun, C.D, McCormack, A, Zhang, R.G, Wang, J.H, Springer, T.A. | | Deposit date: | 2002-08-28 | | Release date: | 2003-01-28 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Structures of the alphaL I Domain and its Complex with ICAM-1 reveal a Shape-shifting Pathway for Integrin Regulation
Cell(Cambridge,Mass.), 112, 2003
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1M1U
 | | AN ISOLEUCINE-BASED ALLOSTERIC SWITCH CONTROLS AFFINITY AND SHAPE SHIFTING IN INTEGRIN CD11B A-DOMAIN | | Descriptor: | CALCIUM ION, Integrin alpha-M | | Authors: | Xiong, J.-P, Li, R, Essafi, M, Stehle, T, Arnaout, M.A. | | Deposit date: | 2002-06-20 | | Release date: | 2002-08-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | An isoleucine-based allosteric switch controls affinity and shape shifting in integrin CD11b A-domain.
J.Biol.Chem., 275, 2000
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1MF7
 | | INTEGRIN ALPHA M I DOMAIN | | Descriptor: | INTEGRIN ALPHA M | | Authors: | McCleverty, C.J, Liddington, R.C. | | Deposit date: | 2002-08-09 | | Release date: | 2003-05-20 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Engineered allosteric mutants of the integrin alphaMbeta2 I domain: structural and functional studies
Biochem.J., 372, 2003
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1MQA
 | | Crystal structure of high affinity alphaL I domain in the absence of ligand or metal | | Descriptor: | Integrin alpha-L | | Authors: | Shimaoka, T, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, Zhang, R, Takagi, J, Wang, J.-H, Springer, T.A. | | Deposit date: | 2002-09-15 | | Release date: | 2003-01-14 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
Cell(Cambridge,Mass.), 112, 2003
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1MQ9
 | | Crystal structure of high affinity alphaL I domain with ligand mimetic crystal contact | | Descriptor: | Integrin alpha-L, MANGANESE (II) ION | | Authors: | Shimaoka, M, Xiao, T, Liu, J.-H, Yang, Y, Dong, Y, Jun, C.-D, McCormack, A, Zhang, R, Joachimiak, A, Takagi, J, Wang, J.-H, Springer, T.A. | | Deposit date: | 2002-09-15 | | Release date: | 2003-01-14 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structures of the aL I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation
Cell(Cambridge,Mass.), 112, 2003
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1SHU
 | | Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor | | Descriptor: | Anthrax toxin receptor 2, MAGNESIUM ION | | Authors: | Lacy, D.B, Wigelsworth, D.J, Scobie, H.M, Young, J.A.T, Collier, R.J. | | Deposit date: | 2004-02-26 | | Release date: | 2004-04-13 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal Structure of the von Willebrand factor A domain of human capillary morphogenesis protein 2: an anthrax toxin receptor
Proc.Natl.Acad.Sci.USA, 101, 2004
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7P2D
 | | Structure of alphaMbeta2/Cd11bCD18 headpiece in complex with a nanobody | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Jensen, R.K, Andersen, G.R. | | Deposit date: | 2021-07-05 | | Release date: | 2022-05-04 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural insights into the function-modulating effects of nanobody binding to the integrin receptor alpha M beta 2.
J.Biol.Chem., 298, 2022
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7AKK
 | | Structure of a complement factor-receptor complex | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement C3 beta chain, Complement C3b alpha' chain, ... | | Authors: | Fernandez, F.J, Santos-Lopez, J, Martinez-Barricarte, R, Querol-Garcia, J, Navas-Yuste, S, Savko, M, Shepard, W.E, Rodriguez de Cordoba, S, Vega, M.C. | | Deposit date: | 2020-10-01 | | Release date: | 2022-04-13 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.395 Å) | | Cite: | The crystal structure of iC3b-CR3 alpha I reveals a modular recognition of the main opsonin iC3b by the CR3 integrin receptor
Nat Commun, 13, 2022
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8IF3
 | | Structure of human alpha-2/delta-1 with mirogabalin | | Descriptor: | 2-[(1R,5S,6S)-6-(aminomethyl)-3-ethyl-6-bicyclo[3.2.0]hept-3-enyl]acetic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Kozai, D, Numoto, N, Fujiyoshi, Y. | | Deposit date: | 2023-02-17 | | Release date: | 2023-04-05 | | Last modified: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human alpha 2 delta 1, a Voltage-Gated Calcium Channel Subunit.
J.Mol.Biol., 435, 2023
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8IF4
 | | Structure of human alpha-2/delta-1 without mirogabalin | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Voltage-dependent calcium channel subunit alpha-2/delta-1 | | Authors: | Kozai, D, Numoto, N, Fujiyoshi, Y. | | Deposit date: | 2023-02-17 | | Release date: | 2023-04-05 | | Last modified: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human alpha 2 delta 1, a Voltage-Gated Calcium Channel Subunit.
J.Mol.Biol., 435, 2023
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5A8J
 | | Crystal structure of the ArnB paralog VWA2 from Sulfolobus acidocaldarius | | Descriptor: | CHLORIDE ION, CITRIC ACID, GLYCEROL, ... | | Authors: | Hoffmann, L, Anders, K, Reimann, J, Linne, U, Essen, L.-O, Albers, S.-V. | | Deposit date: | 2015-07-16 | | Release date: | 2016-06-22 | | Method: | X-RAY DIFFRACTION (1.46 Å) | | Cite: | Phosphorylation-Dependent Interaction between an Archaeal Von Willebrand and Fha Domain Recruits Arna-Arnb Complex to DNA for Repression of Motility
To be Published
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7XLQ
 | | Structure of human R-type voltage-gated CaV2.3-alpha2/delta1-beta1 channel complex in the ligand-free (apo) state | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Gao, Y, Qiu, Y, Wei, Y, Dong, Y, Zhang, X.C, Zhao, Y. | | Deposit date: | 2022-04-22 | | Release date: | 2023-02-08 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
Nat Commun, 14, 2023
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