1RD4
An allosteric inhibitor of LFA-1 bound to its I-domain
Summary for 1RD4
Entry DOI | 10.2210/pdb1rd4/pdb |
Descriptor | Integrin alpha-L, 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE (2 entities in total) |
Functional Keywords | immune system |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane ; Single-pass type I membrane protein : P20701 |
Total number of polymer chains | 4 |
Total formula weight | 88593.84 |
Authors | Crump, M.P.,Ceska, T.A.,Spyracopoulos, L.,Henry, A.,Archibald, S.C.,Alexander, R.,Taylor, R.J.,Findlow, S.C.,O'Connell, J.,Robinson, M.K.,Shock, A. (deposition date: 2003-11-05, release date: 2004-03-30, Last modification date: 2023-08-23) |
Primary citation | Crump, M.P.,Ceska, T.A.,Spyracopoulos, L.,Henry, A.,Archibald, S.C.,Alexander, R.,Taylor, R.J.,Findlow, S.C.,O'Connell, J.,Robinson, M.K.,Shock, A. Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry Biochemistry, 43:2394-2404, 2004 Cited by PubMed: 14992576DOI: 10.1021/bi035422a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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