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1RD4

An allosteric inhibitor of LFA-1 bound to its I-domain

Summary for 1RD4
Entry DOI10.2210/pdb1rd4/pdb
DescriptorIntegrin alpha-L, 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE (2 entities in total)
Functional Keywordsimmune system
Biological sourceHomo sapiens (human)
Cellular locationCell membrane ; Single-pass type I membrane protein : P20701
Total number of polymer chains4
Total formula weight88593.84
Authors
Crump, M.P.,Ceska, T.A.,Spyracopoulos, L.,Henry, A.,Archibald, S.C.,Alexander, R.,Taylor, R.J.,Findlow, S.C.,O'Connell, J.,Robinson, M.K.,Shock, A. (deposition date: 2003-11-05, release date: 2004-03-30, Last modification date: 2023-08-23)
Primary citationCrump, M.P.,Ceska, T.A.,Spyracopoulos, L.,Henry, A.,Archibald, S.C.,Alexander, R.,Taylor, R.J.,Findlow, S.C.,O'Connell, J.,Robinson, M.K.,Shock, A.
Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry
Biochemistry, 43:2394-2404, 2004
Cited by
PubMed: 14992576
DOI: 10.1021/bi035422a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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