8IF3

Structure of human alpha-2/delta-1 with mirogabalin

Summary for 8IF3

Entry DOI	10.2210/pdb8if3/pdb
EMDB information	35399
Descriptor	Voltage-dependent calcium channel subunit alpha-2/delta-1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	gabapentinoid, cache domain, cryo-em, membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	127019.61
Authors	Kozai, D.,Numoto, N.,Fujiyoshi, Y. (deposition date: 2023-02-17, release date: 2023-04-05, Last modification date: 2023-04-12)
Primary citation	Kozai, D.,Numoto, N.,Nishikawa, K.,Kamegawa, A.,Kawasaki, S.,Hiroaki, Y.,Irie, K.,Oshima, A.,Hanzawa, H.,Shimada, K.,Kitano, Y.,Fujiyoshi, Y. Recognition Mechanism of a Novel Gabapentinoid Drug, Mirogabalin, for Recombinant Human alpha 2 delta 1, a Voltage-Gated Calcium Channel Subunit. J.Mol.Biol., 435:168049-168049, 2023 Cited by PubMed: 36933823 DOI: 10.1016/j.jmb.2023.168049 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation