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2QYM
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BU of 2qym by Molmil
crystal structure of unliganded PDE4C2
Descriptor: MAGNESIUM ION, Phosphodiesterase 4C, ZINC ION
Authors:Ke, H.
Deposit date:2007-08-15
Release date:2008-04-08
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors.
Biochem.J., 408, 2007
7L28
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BU of 7l28 by Molmil
Crystal structure of the catalytic domain of human PDE3A bound to Trequinsin
Descriptor: (2E)-9,10-dimethoxy-3-methyl-2-[(2,4,6-trimethylphenyl)imino]-2,3,6,7-tetrahydro-4H-pyrimido[6,1-a]isoquinolin-4-one, ACETATE ION, MAGNESIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-12-16
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
7L29
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BU of 7l29 by Molmil
Crystal structure of the catalytic domain of human PDE3A bound to AMP
Descriptor: ACETATE ION, ADENOSINE MONOPHOSPHATE, CALCIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-12-16
Release date:2021-06-16
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
7L27
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BU of 7l27 by Molmil
Crystal structure of the catalytic domain of human PDE3A
Descriptor: ACETATE ION, CALCIUM ION, MAGNESIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-12-16
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
7KWE
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BU of 7kwe by Molmil
Crystal structure of the catalytic domain of human PDE3A bound to DNMDP
Descriptor: (4~{R})-3-[4-(diethylamino)-3-[oxidanyl(oxidanylidene)-$l^{4}-azanyl]phenyl]-4-methyl-4,5-dihydro-1~{H}-pyridazin-6-one, ACETATE ION, MAGNESIUM ION, ...
Authors:Horner, S.W, Garvie, C.
Deposit date:2020-11-30
Release date:2021-06-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.
Nat Commun, 12, 2021
2FM0
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BU of 2fm0 by Molmil
Crystal structure of PDE4D in complex with L-869298
Descriptor: (S)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHY L)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
Authors:Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
Deposit date:2006-01-06
Release date:2006-03-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2FM5
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BU of 2fm5 by Molmil
Crystal structure of PDE4D2 in complex with inhibitor L-869299
Descriptor: (R)-3-(2-(3-CYCLOPROPOXY-4-(DIFLUOROMETHOXY)PHENYL)-2-(5-(1,1,1,3,3,3-HEXAFLUORO-2-HYDROXYPROPAN-2-YL)THIAZOL-2-YL)ETHYL)PYRIDINE 1-OXIDE, MAGNESIUM ION, ZINC ION, ...
Authors:Huai, Q, Sun, Y, Wang, H, Macdonald, D, Aspiotis, R, Robinson, H, Huang, Z, Ke, H.
Deposit date:2006-01-07
Release date:2006-03-28
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2HD1
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BU of 2hd1 by Molmil
Crystal structure of PDE9 in complex with IBMX
Descriptor: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, Phosphodiesterase 9A, ...
Authors:Huai, Q, Wang, H, Zhang, W, Colman, R.W, Robinson, H, Ke, H.
Deposit date:2006-06-19
Release date:2006-06-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding
Proc.Natl.Acad.Sci.USA, 101, 2004
2H40
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BU of 2h40 by Molmil
Crystal structure of the catalytic domain of unliganded PDE5
Descriptor: MAGNESIUM ION, ZINC ION, cGMP-specific 3',5'-cyclic phosphodiesterase
Authors:Wang, H, Liu, Y, Huai, Q, Cai, J, Zoraghi, R, Francis, S.H, Corbin, J.D, Robinson, H, Xin, Z, Lin, G, Ke, H.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
2H42
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BU of 2h42 by Molmil
Crystal structure of PDE5 in complex with sildenafil
Descriptor: 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, MAGNESIUM ION, ZINC ION, ...
Authors:Wang, H, Ke, H.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
2H44
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BU of 2h44 by Molmil
Crystal structure of PDE5A1 in complex with icarisid II
Descriptor: 5,7-DIHYDROXY-2-(4-METHOXYPHENYL)-8-(3-METHYLBUTYL)-4-OXO-4H-CHROMEN-3-YL 6-DEOXY-ALPHA-L-MANNOPYRANOSIDE, MAGNESIUM ION, ZINC ION, ...
Authors:Wang, H, Ke, H.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
4HTZ
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BU of 4htz by Molmil
Crystal structure of PDE2 catalytic domain in space group P1
Descriptor: MAGNESIUM ION, ZINC ION, cGMP-dependent 3',5'-cyclic phosphodiesterase
Authors:Zhu, J, Huang, Q.
Deposit date:2012-11-02
Release date:2013-08-28
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity.
J.Am.Chem.Soc., 135, 2013
4I15
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BU of 4i15 by Molmil
Crystal structure of TbrPDEB1
Descriptor: Class 1 phosphodiesterase PDEB1, MAGNESIUM ION, ZINC ION
Authors:Wang, H, Ke, H.
Deposit date:2012-11-20
Release date:2013-03-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery of Novel Trypanosoma brucei Phosphodiesterase B1 Inhibitors by Virtual Screening against the Unliganded TbrPDEB1 Crystal Structure.
J.Med.Chem., 56, 2013
7F0I
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BU of 7f0i by Molmil
phosphodiesterase-9A in complex with inhibitor 4b
Descriptor: 1-cyclopentyl-6-[[(2R)-1-(6-fluoranyl-2-azaspiro[3.3]heptan-2-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, Isoform PDE9A2 of High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
Authors:Wu, Y, Huang, Y.Y, Luo, H.B.
Deposit date:2021-06-04
Release date:2022-04-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.70000887 Å)
Cite:Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis
J.Med.Chem., 64, 2021
7FAR
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BU of 7far by Molmil
Crystal structure of PDE5A in complex with inhibitor L12
Descriptor: 5-[bis(fluoranyl)methoxy]-2-[(4-chlorophenyl)methyl]-10-(3-methoxypropyl)-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one, MAGNESIUM ION, ZINC ION, ...
Authors:Wu, D, Huang, Y.Y, Luo, H.B.
Deposit date:2021-07-07
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.40006471 Å)
Cite:Free energy perturbation (FEP)-guided scaffold hopping.
Acta Pharm Sin B, 12, 2022
4IA0
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BU of 4ia0 by Molmil
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Descriptor: 5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ...
Authors:Ren, J, Chen, T, Xu, Y.
Deposit date:2012-12-05
Release date:2014-01-01
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
7FAQ
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BU of 7faq by Molmil
Crystal structure of PDE5A in complex with inhibitor L1
Descriptor: 2-[(4-chlorophenyl)methyl]-5-methoxy-3,10-diazatricyclo[6.4.1.0^{4,13}]trideca-1,4(13),5,7-tetraen-9-one, MAGNESIUM ION, SULFATE ION, ...
Authors:Wu, D, Huang, Y.Y, Luo, H.B.
Deposit date:2021-07-07
Release date:2022-05-18
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.200136 Å)
Cite:Free energy perturbation (FEP)-guided scaffold hopping.
Acta Pharm Sin B, 12, 2022
6QGU
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BU of 6qgu by Molmil
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1361
Descriptor: 5-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-isopropyl-4,4-dimethyl-2,4-dihydro-3H-pyrazol-3-one, FORMIC ACID, GLYCEROL, ...
Authors:Singh, A.K, Blaazer, A.R, Zara, L, de Esch, I.J.P, Leurs, R, Brown, D.G.
Deposit date:2019-01-13
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1361
To be published
6QGP
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BU of 6qgp by Molmil
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-0769
Descriptor: 1-cycloheptyl-3-[3-(cyclopentyloxy)-4-methoxyphenyl]-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ...
Authors:Singh, A.K, Blaazer, A.R, Zara, L, de Esch, I.J.P, Leurs, R, Brown, D.G.
Deposit date:2019-01-12
Release date:2020-02-05
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.942 Å)
Cite:Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-0769
To be published
8WDN
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BU of 8wdn by Molmil
Crystal structure of PDE4D complexed with 7b-1
Descriptor: 1,2-ETHANEDIOL, 3-[(2~{S},3~{R})-7-ethoxy-2-(3-ethoxy-4-methoxy-phenyl)-3-(hydroxymethyl)-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol, MAGNESIUM ION, ...
Authors:Liu, J.Y, Li, M.J, Xu, Y.C.
Deposit date:2023-09-15
Release date:2024-08-28
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model.
J.Med.Chem., 67, 2024
8WDO
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BU of 8wdo by Molmil
Crystal structure of PDE4D complexed with DCN
Descriptor: 1,2-ETHANEDIOL, 3-[(2~{S},3~{R})-2-(3,4-dimethoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]propan-1-ol, MAGNESIUM ION, ...
Authors:Liu, J.Y, Li, M.J, Xu, Y.C.
Deposit date:2023-09-15
Release date:2024-08-28
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model.
J.Med.Chem., 67, 2024
4G2W
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BU of 4g2w by Molmil
Crystal structure of PDE5A in complex with its inhibitor
Descriptor: 5,6-diethyl-2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
Authors:Ren, J, Chen, T.T, Xu, Y.C.
Deposit date:2012-07-13
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.
J.Med.Chem., 55, 2012
6RB6
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BU of 6rb6 by Molmil
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-053
Descriptor: 1,2-ETHANEDIOL, 3-[5-[(4~{a}~{R},8~{a}~{S})-3-cycloheptyl-4-oxidanylidene-4~{a},5,8,8~{a}-tetrahydrophthalazin-1-yl]-2-methoxy-phenyl]-~{N}-(furan-2-ylmethyl)prop-2-ynamide, FORMIC ACID, ...
Authors:Singh, A.K, Brown, D.G.
Deposit date:2019-04-09
Release date:2019-07-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2).
Bioorg.Med.Chem., 27, 2019
6A3N
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BU of 6a3n by Molmil
Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2
Descriptor: 1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
Authors:Wu, Y.N, Zhou, Q, Chen, Y.P, Luo, H.B.
Deposit date:2018-06-15
Release date:2019-04-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.
J. Med. Chem., 62, 2019
4G2Y
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BU of 4g2y by Molmil
Crystal structure of PDE5A complexed with its inhibitor
Descriptor: 2-{5-[(4-methylpiperazin-1-yl)sulfonyl]-2-propoxyphenyl}-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ...
Authors:Ren, J, Chen, T.T, Xu, Y.C.
Deposit date:2012-07-13
Release date:2013-06-26
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5.
J.Med.Chem., 55, 2012

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