7FAR

Crystal structure of PDE5A in complex with inhibitor L12

Summary for 7FAR

Entry DOI	10.2210/pdb7far/pdb
Descriptor	cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase-inhibitor complex, hydrolase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40804.85
Authors	Wu, D.,Huang, Y.Y.,Luo, H.B. (deposition date: 2021-07-07, release date: 2022-05-18, Last modification date: 2023-11-29)
Primary citation	Wu, D.,Zheng, X.,Liu, R.,Li, Z.,Jiang, Z.,Zhou, Q.,Huang, Y.,Wu, X.N.,Zhang, C.,Huang, Y.Y.,Luo, H.B. Free energy perturbation (FEP)-guided scaffold hopping. Acta Pharm Sin B, 12:1351-1362, 2022 Cited by PubMed: 35530128 DOI: 10.1016/j.apsb.2021.09.027 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.40006470991 Å)

Structure validation