7L27

Crystal structure of the catalytic domain of human PDE3A

Summary for 7L27

• Entry DOI: 10.2210/pdb7l27/pdb
• Descriptor: cGMP-inhibited 3',5'-cyclic phosphodiesterase A, MANGANESE (II) ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 173269.71

Authors

Horner, S.W.,Garvie, C. (deposition date: 2020-12-16, release date: 2021-06-16, Last modification date: 2023-10-18)

• Primary citation: Garvie, C.W.,Wu, X.,Papanastasiou, M.,Lee, S.,Fuller, J.,Schnitzler, G.R.,Horner, S.W.,Baker, A.,Zhang, T.,Mullahoo, J.P.,Westlake, L.,Hoyt, S.H.,Toetzl, M.,Ranaghan, M.J.,de Waal, L.,McGaunn, J.,Kaplan, B.,Piccioni, F.,Yang, X.,Lange, M.,Tersteegen, A.,Raymond, D.,Lewis, T.A.,Carr, S.A.,Cherniack, A.D.,Lemke, C.T.,Meyerson, M.,Greulich, H.; Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase.; Nat Commun, 12:4375-4375, 2021; PubMed: 34272366; DOI: 10.1038/s41467-021-24495-w

Experimental method

X-RAY DIFFRACTION (1.7 Å)