6RB6
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-053
Summary for 6RB6
Entry DOI | 10.2210/pdb6rb6/pdb |
Related | 6GXQ 6HWO |
Descriptor | Phosphodiesterase, MAGNESIUM ION, ZINC ION, ... (8 entities in total) |
Functional Keywords | parasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 83784.81 |
Authors | Singh, A.K.,Brown, D.G. (deposition date: 2019-04-09, release date: 2019-07-24, Last modification date: 2024-01-24) |
Primary citation | de Heuvel, E.,Singh, A.K.,Boronat, P.,Kooistra, A.J.,van der Meer, T.,Sadek, P.,Blaazer, A.R.,Shaner, N.C.,Bindels, D.S.,Caljon, G.,Maes, L.,Sterk, G.J.,Siderius, M.,Oberholzer, M.,de Esch, I.J.P.,Brown, D.G.,Leurs, R. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg.Med.Chem., 27:4013-4029, 2019 Cited by PubMed: 31378593DOI: 10.1016/j.bmc.2019.06.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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