Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1001 |
| Chain | Residue |
| A | ASP710 |
| A | HOH1123 |
| A | HOH1145 |
| A | HOH1190 |
| A | HOH1196 |
| A | HOH1277 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | ASP822 |
| A | HOH1145 |
| A | HOH1241 |
| A | HIS673 |
| A | HIS709 |
| A | ASP710 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 1003 |
| Chain | Residue |
| A | GLY638 |
| A | SER639 |
| A | HIS682 |
| A | HOH1243 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 1004 |
| Chain | Residue |
| A | LEU753 |
| A | SER754 |
| A | ASP759 |
| A | ASP762 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 1005 |
| Chain | Residue |
| A | LEU694 |
| A | HOH1157 |
| A | HOH1168 |
| A | HOH1234 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 1006 |
| Chain | Residue |
| A | ALA799 |
| A | ALA800 |
| A | ASP801 |
| A | GLN802 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | binding site for residue GAI A 1007 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue GAI A 1008 |
| Chain | Residue |
| A | ASP712 |
| A | MET714 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue GAI A 1009 |
| Chain | Residue |
| A | SER639 |
| A | GLU696 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1010 |
| Chain | Residue |
| A | PHE605 |
| A | ASP606 |
| A | ASP609 |
| A | HOH1199 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1011 |
| Chain | Residue |
| A | GLY688 |
| A | ASN689 |
| A | LEU894 |
| A | GLN895 |
| A | GLY896 |
| A | HOH1235 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1012 |
| Chain | Residue |
| A | GLU698 |
| A | LEU771 |
| A | HIS810 |
| A | HOH1155 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 1013 |
| Chain | Residue |
| A | ARG903 |
| A | HOH1125 |
| A | HOH1177 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue JX2 A 1014 |
| Chain | Residue |
| A | MET785 |
| A | ASP822 |
| A | VAL840 |
| A | GLY873 |
| A | GLN874 |
| A | GLY876 |
| A | PHE877 |
| A | HOH1178 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue GAI B 1001 |
| Chain | Residue |
| A | GLU692 |
| A | LYS693 |
| A | HIS810 |
| B | PHE645 |
| B | GLY646 |
| B | GLY763 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue FMT B 1002 |
| Chain | Residue |
| A | THR770 |
| B | GLU725 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1003 |
| Chain | Residue |
| B | ASP710 |
| B | HOH1118 |
| B | HOH1139 |
| B | HOH1203 |
| B | HOH1226 |
| B | HOH1245 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 1004 |
| Chain | Residue |
| B | HIS673 |
| B | HIS709 |
| B | ASP710 |
| B | ASP822 |
| B | HOH1118 |
| B | HOH1213 |
| site_id | AE1 |
| Number of Residues | 1 |
| Details | binding site for residue GAI B 1005 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue GAI B 1006 |
| Chain | Residue |
| B | ASP712 |
| B | MET714 |
| B | TYR721 |
| B | LEU728 |
| B | LEU741 |
| B | HIS744 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1007 |
| Chain | Residue |
| B | PHE605 |
| B | GLU611 |
| B | PHE612 |
| B | ASP613 |
| B | ARG616 |
| B | EDO1009 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1008 |
| Chain | Residue |
| B | PHE615 |
| B | ARG618 |
| B | PRO667 |
| B | ASN670 |
| B | TYR672 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1009 |
| Chain | Residue |
| B | ASP609 |
| B | EDO1007 |
| B | SER604 |
| B | PHE605 |
| B | ASP606 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 1010 |
| Chain | Residue |
| B | SER719 |
| B | LYS723 |
| B | GLN847 |
| B | GLU851 |
| B | VAL858 |
| B | LEU859 |
| B | PHE862 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1011 |
| Chain | Residue |
| B | GLY688 |
| B | ASN689 |
| B | LEU894 |
| B | GLN895 |
| B | GLY896 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue JX2 B 1012 |
| Chain | Residue |
| B | MET785 |
| B | TYR845 |
| B | MET861 |
| B | ASN867 |
| B | LYS872 |
| B | GLY873 |
| B | GLN874 |
| B | PHE877 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue GAI B 1013 |
| Chain | Residue |
| A | LYS644 |
| A | THR695 |
| A | LEU697 |
| A | HOH1174 |
| B | ASP649 |
| site_id | AF1 |
| Number of Residues | 2 |
| Details | binding site for residue GAI B 1014 |
| Chain | Residue |
| B | MET812 |
| B | GLU815 |
| site_id | AF2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 1015 |
| Chain | Residue |
| B | GLN895 |
| B | HOH1210 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF |
| Chain | Residue | Details |
| A | HIS709-PHE720 | |
