6GXQ
Crystal structure of T. brucei PDE-B1 catalytic domain with inhibitor NPD-1335
Summary for 6GXQ
Entry DOI | 10.2210/pdb6gxq/pdb |
Descriptor | Phosphodiesterase, MAGNESIUM ION, ZINC ION, ... (7 entities in total) |
Functional Keywords | parasitic phosphodiesterase, hydrolase, african trypanosomiasis, sleeping sickness |
Biological source | Trypanosoma brucei |
Total number of polymer chains | 2 |
Total formula weight | 82453.29 |
Authors | Singh, A.K.,Brown, D.G. (deposition date: 2018-06-27, release date: 2019-07-10, Last modification date: 2024-01-17) |
Primary citation | de Heuvel, E.,Singh, A.K.,Boronat, P.,Kooistra, A.J.,van der Meer, T.,Sadek, P.,Blaazer, A.R.,Shaner, N.C.,Bindels, D.S.,Caljon, G.,Maes, L.,Sterk, G.J.,Siderius, M.,Oberholzer, M.,de Esch, I.J.P.,Brown, D.G.,Leurs, R. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg.Med.Chem., 27:4013-4029, 2019 Cited by PubMed: 31378593DOI: 10.1016/j.bmc.2019.06.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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