1N4L
| A DNA analogue of the polypurine tract of HIV-1 | Descriptor: | 5'-D(*CP*TP*TP*TP*TP*CP*TP*TP*TP*TP*AP*AP*AP*AP*AP*G)-3', 5'-D(*CP*TP*TP*TP*TP*TP*AP*AP*AP*AP*GP*AP*AP*AP*AP*G)-3', Reverse Transcriptase | Authors: | Cote, M.L, Pflomm, M, Georgiadis, M.M. | Deposit date: | 2002-10-31 | Release date: | 2003-06-24 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Staying Straight with A-tracts: A DNA Analog of the HIV-1 Polypurine Tract J.Mol.Biol., 330, 2003
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1HAR
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1NND
| Arginine 116 is Essential for Nucleic Acid Recognition by the Fingers Domain of Moloney Murine Leukemia Virus Reverse Transcriptase | Descriptor: | Reverse Transcriptase | Authors: | Crowther, R.L, Remeta, D.P, Minetti, C.A, Das, D, Montano, S.P, Georgiadis, M.M. | Deposit date: | 2003-01-13 | Release date: | 2004-01-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and energetic characterization of nucleic acid-binding to the fingers domain of Moloney murine leukemia virus reverse transcriptase Proteins, 57, 2004
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1I6J
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6B1R
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1QAJ
| CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), REVERSE TRANSCRIPTASE | Authors: | Najmudin, S, Cote, M, Sun, D, Yohannan, S, Montano, S.P, Gu, J, Georgiadis, M.M. | Deposit date: | 1999-03-18 | Release date: | 2000-04-02 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain. J.Mol.Biol., 296, 2000
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6B1S
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6B1Q
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1QAI
| CRYSTAL STRUCTURES OF THE N-TERMINAL FRAGMENT FROM MOLONEY MURINE LEUKEMIA VIRUS REVERSE TRANSCRIPTASE COMPLEXED WITH NUCLEIC ACID: FUNCTIONAL IMPLICATIONS FOR TEMPLATE-PRIMER BINDING TO THE FINGERS DOMAIN | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*CP*AP*TP*G)-3'), MERCURY (II) ION, REVERSE TRANSCRIPTASE | Authors: | Najmudin, S, Cote, M, Sun, D, Yohannan, S, Montano, S.P, Gu, J, Georgiadis, M.M. | Deposit date: | 1999-03-12 | Release date: | 2000-03-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structures of an N-terminal fragment from Moloney murine leukemia virus reverse transcriptase complexed with nucleic acid: functional implications for template-primer binding to the fingers domain. J.Mol.Biol., 296, 2000
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1MML
| MECHANISTIC IMPLICATIONS FROM THE STRUCTURE OF A CATALYTIC FRAGMENT OF MMLV REVERSE TRANSCRIPTASE | Descriptor: | MMLV REVERSE TRANSCRIPTASE | Authors: | Georgiadis, M.M, Jessen, S.M, Ogata, C.M, Telesnitsky, A, Goff, S.P, Hendrickson, W.A. | Deposit date: | 1995-07-18 | Release date: | 1995-10-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase. Structure, 3, 1995
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6ZDU
| Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA | Descriptor: | Chains: C,D, Telomerase reverse transcriptase | Authors: | Zhai, L, Rety, S, Chen, W.F, Auguin, D, Xi, X.G. | Deposit date: | 2020-06-15 | Release date: | 2021-04-28 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡. Nucleic Acids Res., 49, 2021
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6ZDQ
| Structure of telomerase from Candida albicans in complexe with TWJ fragment of telomeric RNA | Descriptor: | RNA, Telomerase reverse transcriptase | Authors: | Zhai, L, Rety, S, Chen, W.F, Auguin, D, Xi, X.G. | Deposit date: | 2020-06-15 | Release date: | 2021-04-28 | Last modified: | 2021-05-12 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Crystal structures of N-terminally truncated telomerase reverse transcriptase from fungi‡. Nucleic Acids Res., 49, 2021
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8FLI
| Cryo-EM structure of a group II intron immediately before branching | Descriptor: | Group II Intron, MAGNESIUM ION, Maturase reverse transcriptase | Authors: | Haack, D.B, Rudolfs, B.G, Zhang, C, Lyumkis, D, Toor, N. | Deposit date: | 2022-12-21 | Release date: | 2023-12-13 | Last modified: | 2024-02-07 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis of branching during RNA splicing. Nat.Struct.Mol.Biol., 31, 2024
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6E53
| Structure of TERT in complex with a novel telomerase inhibitor | Descriptor: | MAGNESIUM ION, RNA/DNA hairpin, Telomerase reverse transcriptase, ... | Authors: | Hernandez-Sanchez, W, Huang, W, Plucinsky, B, Garcia-Vazquez, N, Berdis, A.J, Skordalakes, E, Taylor, D.J. | Deposit date: | 2018-07-19 | Release date: | 2019-03-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A non-natural nucleotide uses a specific pocket to selectively inhibit telomerase activity. Plos Biol., 17, 2019
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5CQG
| Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532 | Descriptor: | 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid, Telomerase reverse transcriptase | Authors: | Bryan, C, Rice, C, Hoffman, H, Harkisheimer, M, Sweeney, M, Skordalakes, E. | Deposit date: | 2015-07-21 | Release date: | 2015-09-09 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure, 23, 2015
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8H2H
| Cryo-EM structure of a Group II Intron Complexed with its Reverse Transcriptase | Descriptor: | Group II intron-encoded protein LtrA, LtrB, RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3') | Authors: | Liu, N, Dong, X.L, Qu, G.S, Wang, J, Wang, H.W, Belfort, M. | Deposit date: | 2022-10-06 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Functionalized graphene grids with various charges for single-particle cryo-EM. Nat Commun, 13, 2022
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7BG9
| The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate | Descriptor: | DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3'), Histone H2A, Histone H2B, ... | Authors: | Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. | Deposit date: | 2021-01-06 | Release date: | 2021-04-28 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of human telomerase holoenzyme with bound telomeric DNA. Nature, 593, 2021
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7D0F
| cryo-EM structure of a pre-catalytic group II intron RNP | Descriptor: | Group II intron-encoded protein LtrA, RNA (738-MER) | Authors: | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | Deposit date: | 2020-09-10 | Release date: | 2020-09-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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7D0G
| Cryo-EM structure of a pre-catalytic group II intron | Descriptor: | Group II intron-encoded protein LtrA, RNA (714-MER) | Authors: | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | Deposit date: | 2020-09-10 | Release date: | 2020-09-30 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5 Å) | Cite: | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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7D1A
| cryo-EM structure of a group II intron RNP complexed with its reverse transcriptase | Descriptor: | Group II intron-encoded protein LtrA, RNA (5'-R(P*CP*AP*CP*AP*UP*CP*CP*AP*UP*AP*AP*C)-3'), RNA (692-MER) | Authors: | Liu, N, Dong, X.L, Hu, C.X, Zeng, J.W, Wang, J.W, Wang, J, Wang, H.W, Belfort, M. | Deposit date: | 2020-09-14 | Release date: | 2020-10-21 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Exon and protein positioning in a pre-catalytic group II intron RNP primed for splicing. Nucleic Acids Res., 48, 2020
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7O0H
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6ME0
| Structure of a group II intron retroelement prior to DNA integration | Descriptor: | MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ... | Authors: | Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N. | Deposit date: | 2018-09-05 | Release date: | 2019-08-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. Cell, 178, 2019
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6MEC
| Structure of a group II intron retroelement after DNA integration | Descriptor: | MAGNESIUM ION, Maturase reverse transcriptase, SODIUM ION, ... | Authors: | Haack, D, Yan, X, Zhang, C, Hingey, J, Lyumkis, D, Baker, T.S, Toor, N. | Deposit date: | 2018-09-06 | Release date: | 2019-08-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM Structures of a Group II Intron Reverse Splicing into DNA. Cell, 178, 2019
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4OL8
| Ty3 reverse transcriptase bound to DNA/RNA | Descriptor: | 5'-D(*CP*AP*TP*CP*TP*TP*CP*CP*TP*CP*TP*CP*TP*CP*TP*C)-3', 5'-R(*CP*UP*GP*AP*GP*AP*GP*AP*GP*AP*GP*GP*AP*AP*GP*AP*UP*G)-3', Reverse transcriptase/ribonuclease H, ... | Authors: | Nowak, E, Miller, J.T, Bona, M.K, Studnicka, J, Szczepanowski, R.H, Jurkowski, J, Le Grice, S.F.J, Nowotny, M. | Deposit date: | 2014-01-23 | Release date: | 2014-03-05 | Last modified: | 2014-04-16 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry. Nat.Struct.Mol.Biol., 21, 2014
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7Q5B
| Cryo-EM structure of Ty3 retrotransposon targeting a TFIIIB-bound tRNA gene | Descriptor: | DNA (19-MER), DNA (31-MER), DNA (34-MER), ... | Authors: | Abascal-Palacios, G, Jochem, L, Pla-Prats, C, Beuron, F, Vannini, A. | Deposit date: | 2021-11-03 | Release date: | 2022-01-26 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structural basis of Ty3 retrotransposon integration at RNA Polymerase III-transcribed genes. Nat Commun, 12, 2021
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