5CQG
Structure of Tribolium telomerase in complex with the highly specific inhibitor BIBR1532
Summary for 5CQG
Entry DOI | 10.2210/pdb5cqg/pdb |
Descriptor | Telomerase reverse transcriptase, 2-{[(2E)-3-(naphthalen-2-yl)but-2-enoyl]amino}benzoic acid (3 entities in total) |
Functional Keywords | telomerase reverse transcriptase fold tert bibr15312, telomerase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Tribolium castaneum (Red flour beetle) |
Total number of polymer chains | 2 |
Total formula weight | 141840.17 |
Authors | Bryan, C.,Rice, C.,Hoffman, H.,Harkisheimer, M.,Sweeney, M.,Skordalakes, E. (deposition date: 2015-07-21, release date: 2015-09-09, Last modification date: 2023-09-27) |
Primary citation | Bryan, C.,Rice, C.,Hoffman, H.,Harkisheimer, M.,Sweeney, M.,Skordalakes, E. Structural Basis of Telomerase Inhibition by the Highly Specific BIBR1532. Structure, 23:1934-1942, 2015 Cited by PubMed: 26365799DOI: 10.1016/j.str.2015.08.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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