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4NVP
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Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP
Descriptor: (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Alfieri, A, Moroni, A.
Deposit date:2013-12-05
Release date:2014-03-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014
5C8W
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BU of 5c8w by Molmil
PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, MALONIC ACID, SODIUM ION, ...
Authors:Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W.
Deposit date:2015-06-26
Release date:2016-01-20
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
4MUV
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BU of 4muv by Molmil
M. loti cyclic-nucleotide binding domain mutant displaying inverted ligand selectivity, cyclic-GMP bound
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated potassium channel mll3241, SODIUM ION
Authors:Fonseca, F, Pessoa, J, Morais-Cabral, J.H.
Deposit date:2013-09-23
Release date:2014-06-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Determinants of ligand selectivity in a cyclic nucleotide-regulated potassium channel.
J.Gen.Physiol., 144, 2014
4OFF
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BU of 4off by Molmil
Crystal structure of apo carboxy cGMP binding domain of Plasmodium falciparum PKG
Descriptor: CGMP-dependent protein kinase, SULFATE ION
Authors:Kim, J.J, Sanabria figueroa, E, Kim, C.
Deposit date:2014-01-14
Release date:2015-01-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.888 Å)
Cite:Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.
Plos Pathog., 11, 2015
4OFG
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BU of 4ofg by Molmil
Co-crystal structure of carboxy cGMP binding domain of Plasmodium falciparum PKG with cGMP
Descriptor: CGMP-dependent protein kinase, CYCLIC GUANOSINE MONOPHOSPHATE, ETHANOL, ...
Authors:Kim, J.J, Sanabria figueroa, E, Kim, C.
Deposit date:2014-01-14
Release date:2015-01-21
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of the Carboxyl cGMP Binding Domain of the Plasmodium falciparum cGMP-dependent Protein Kinase Reveal a Novel Capping Triad Crucial for Merozoite Egress.
Plos Pathog., 11, 2015
6FTF
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BU of 6ftf by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.09 A resolution
Descriptor: 1,2-ETHANEDIOL, 7-cyano-7-deazainosine, Protein kinase A regulatory subunit, ...
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-02-21
Release date:2019-04-03
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.09151936 Å)
Cite:Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma.
Nat Commun, 10, 2019
6FLO
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BU of 6flo by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1 Angstrom resolution
Descriptor: GLYCEROL, INOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-01-26
Release date:2019-08-14
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.13868666 Å)
Cite:Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
3GYD
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BU of 3gyd by Molmil
Crystal structure of a cyclic nucleotide-binding domain (mfla_1926) from methylobacillus flagellatus kt at 1.79 A resolution
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Cyclic nucleotide-binding domain, GLYCEROL
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2009-04-03
Release date:2009-04-21
Last modified:2023-02-01
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structure of cyclic nucleotide-binding domain (YP_546034.1) from Methylobacillus flagellatus KT at 1.79 A resolution
To be published
6H4G
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BU of 6h4g by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-07-21
Release date:2019-08-14
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.143517 Å)
Cite:Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
6HQ3
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BU of 6hq3 by Molmil
Structure of EAL Enzyme Bd1971 - halfsite-occupied form
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, EAL Enzyme Bd1971
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
6HQ2
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BU of 6hq2 by Molmil
Structure of EAL Enzyme Bd1971 - apo form
Descriptor: EAL Enzyme Bd1971
Authors:Lovering, A.L, Cadby, I.T.
Deposit date:2018-09-24
Release date:2019-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase.
Embo J., 38, 2019
3IIA
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BU of 3iia by Molmil
Crystal structure of apo (91-244) RIa subunit of cAMP-dependent protein kinase
Descriptor: GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit
Authors:Sjoberg, T.J, Kim, C, Kornev, A.P, Taylor, S.S.
Deposit date:2009-07-31
Release date:2010-08-11
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design.
Mol.Cell Proteomics, 10, 2011
4KL1
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BU of 4kl1 by Molmil
HCN4 CNBD in complex with cGMP
Descriptor: ACETATE ION, CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, ...
Authors:Lolicato, M, Arrigoni, C, Zucca, S, Nardini, M, Bucchi, A, Schroeder, I, Simmons, K, Bolognesi, M, DiFrancesco, D, Schwede, F, Fishwick, C.W.G, Johnson, A.P.K, Thiel, G, Moroni, A.
Deposit date:2013-05-07
Release date:2014-04-30
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Nat.Chem.Biol., 10, 2014
6HYI
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BU of 6hyi by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A resolution in complex with inosine
Descriptor: INOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-10-22
Release date:2019-11-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (1.39944851 Å)
Cite:Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
6HYQ
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BU of 6hyq by Molmil
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi bound to guanosine
Descriptor: ACETATE ION, GUANOSINE, Protein kinase A regulatory subunit
Authors:Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M.
Deposit date:2018-10-22
Release date:2019-11-13
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi in complex with guanosine
to be published
4KU8
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BU of 4ku8 by Molmil
Structures of PKGI Reveal a cGMP-Selective Activation Mechanism
Descriptor: GLYCINE, cGMP-dependent Protein Kinase 1
Authors:Huang, G.Y, Kim, J.J, Reger, A.S, Lorenz, R, Moon, E.W, Casteel, D.E, Sankaran, B, Herberg, F.W, Kim, C.
Deposit date:2013-05-21
Release date:2014-01-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.
Structure, 22, 2014
4KU7
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BU of 4ku7 by Molmil
Structures of PKGI Reveal a cGMP-Selective Activation Mechanism
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, IODIDE ION, cGMP-dependent protein kinase 1
Authors:Huang, G.Y, Kim, J.J, Reger, A.S, Lorenz, R, Moon, E.W, Casteel, D.E, Sankaran, B, Herberg, F.W, Kim, C.
Deposit date:2013-05-21
Release date:2014-01-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Cyclic-Nucleotide Selectivity and cGMP-Selective Activation of PKG I.
Structure, 22, 2014
4JVA
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BU of 4jva by Molmil
Crystal Structure of RIIbeta(108-402) bound to HE33, a N6 di-propyl substituted cAMP analog
Descriptor: (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, cAMP-dependent protein kinase type II-beta regulatory subunit
Authors:Brown, S.H.J, Cheng, C.Y, Saldanha, A.S, Wu, J, Cottam, H, Sankaran, B, Taylor, S.S.
Deposit date:2013-03-25
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs.
Acs Chem.Biol., 8, 2013
4JV4
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BU of 4jv4 by Molmil
Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog
Descriptor: (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, cAMP-dependent protein kinase type I-alpha regulatory subunit
Authors:Brown, S.H.J, Cheng, C.Y, Saldanha, A.S, Wu, J, Cottam, H, Sankaran, B, Taylor, S.S.
Deposit date:2013-03-25
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.952 Å)
Cite:Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs.
Acs Chem.Biol., 8, 2013
4L11
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BU of 4l11 by Molmil
Structure of the C-linker/CNBHD of agERG channels
Descriptor: AGAP007709-PA
Authors:Brelidze, T.I.
Deposit date:2013-06-01
Release date:2013-06-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of the C-terminal region of an ERG channel and functional implications.
Proc.Natl.Acad.Sci.USA, 110, 2013
3OD0
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BU of 3od0 by Molmil
Crystal structure of cGMP bound cGMP-dependent protein kinase(92-227)
Descriptor: CYCLIC GUANOSINE MONOPHOSPHATE, PRKG1 protein
Authors:Kim, J.J, Huang, G, Kwon, T.K, Zwart, P, Headd, J, Kim, C.
Deposit date:2010-08-10
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6, 2011
3PNA
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BU of 3pna by Molmil
Crystal Structure of cAMP bound (91-244)RIa Subunit of cAMP-dependent Protein Kinase
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, cAMP-dependent protein kinase type I-alpha regulatory subunit
Authors:Kim, C, Taylor, S.
Deposit date:2010-11-18
Release date:2011-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.503 Å)
Cite:Cyclic AMP Analog Blocks Kinase Activation by Stabilizing Inactive Conformation: Conformational Selection Highlights a New Concept in Allosteric Inhibitor Design.
Mol Cell Proteomics, 10, 2011
7LZ4
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BU of 7lz4 by Molmil
Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed
Authors:Del Rio, J, Wu, J, Taylor, S.S.
Deposit date:2021-03-08
Release date:2021-05-26
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (4.155 Å)
Cite:Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.
Proc.Natl.Acad.Sci.USA, 118, 2021
3OF1
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BU of 3of1 by Molmil
Crystal Structure of Bcy1, the Yeast Regulatory Subunit of PKA
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, cAMP-dependent protein kinase regulatory subunit
Authors:Rinaldi, J, Wu, J, Yang, J, Ralston, C.Y, Sankaran, B, Moreno, S, Taylor, S.S.
Deposit date:2010-08-13
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling.
Structure, 18, 2010
3OGJ
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BU of 3ogj by Molmil
Crystal structure of partial apo (92-227) of cGMP-dependent protein kinase
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION, PRKG1 protein
Authors:Kim, J.J, Huang, G, Kwon, T.K, Zwart, P, Headd, J, Kim, C.
Deposit date:2010-08-16
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6, 2011

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