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3IIA

Crystal structure of apo (91-244) RIa subunit of cAMP-dependent protein kinase

Summary for 3IIA
Entry DOI10.2210/pdb3iia/pdb
Related1NE4 1NE6 1RGS 1RL3 3FHI
DescriptorcAMP-dependent protein kinase type I-alpha regulatory subunit, GLYCEROL (3 entities in total)
Functional Keywordsprotein kinase a, cyclic amp, ria subunit, camp, camp-binding, disulfide bond, nucleotide-binding, phosphoprotein, transferase
Biological sourceBos taurus (bovine)
Cellular locationCell membrane : P00514
Total number of polymer chains1
Total formula weight17431.66
Authors
Sjoberg, T.J.,Kim, C.,Kornev, A.P.,Taylor, S.S. (deposition date: 2009-07-31, release date: 2010-08-11, Last modification date: 2023-09-06)
Primary citationBadireddy, S.,Yunfeng, G.,Ritchie, M.,Akamine, P.,Wu, J.,Kim, C.W.,Taylor, S.S.,Qingsong, L.,Swaminathan, K.,Anand, G.S.
Cyclic AMP analog blocks kinase activation by stabilizing inactive conformation: conformational selection highlights a new concept in allosteric inhibitor design.
Mol.Cell Proteomics, 10:M110.004390-M110.004390, 2011
Cited by
PubMed: 21081668
DOI: 10.1074/mcp.M110.004390
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

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