7LZ4

Crystal structure of A211D mutant of Protein Kinase A RIa subunit, a Carney Complex mutation

Summary for 7LZ4

• Entry DOI: 10.2210/pdb7lz4/pdb
• Descriptor: cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE (2 entities in total)
• Functional Keywords: carney complex, cyclic nucleotide binding domain, cyclic amp (camp), protein kinase a (pka), transferase
• Biological source: Bos taurus (Bovine)
• Total number of polymer chains: 8
• Total formula weight: 248022.89

Authors

Del Rio, J.,Wu, J.,Taylor, S.S. (deposition date: 2021-03-08, release date: 2021-05-26, Last modification date: 2023-10-18)

• Primary citation: Jafari, N.,Del Rio, J.,Akimoto, M.,Byun, J.A.,Boulton, S.,Moleschi, K.,Alsayyed, Y.,Swanson, P.,Huang, J.,Martinez Pomier, K.,Lee, C.,Wu, J.,Taylor, S.S.,Melacini, G.; Noncanonical protein kinase A activation by oligomerization of regulatory subunits as revealed by inherited Carney complex mutations.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34006641; DOI: 10.1073/pnas.2024716118

Experimental method

X-RAY DIFFRACTION (4.155 Å)