4JV4
Crystal Structure of RIalpha(91-379) bound to HE33, a N6 di-propyl substituted cAMP analog
Summary for 4JV4
Entry DOI | 10.2210/pdb4jv4/pdb |
Related | 1NE4 1NE6 1RGS |
Descriptor | cAMP-dependent protein kinase type I-alpha regulatory subunit, (2R,4aR,6R,7R,7aS)-6-[6-(dipropylamino)-9H-purin-9-yl]tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide (2 entities in total) |
Functional Keywords | camp-dependent protein kinase, cyclic nucleotide analogs, isoform selectivity, fluorescence anisotropy, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Bos taurus (bovine,cow,domestic cattle,domestic cow) |
Cellular location | Cell membrane (By similarity): P00514 |
Total number of polymer chains | 1 |
Total formula weight | 33320.58 |
Authors | Brown, S.H.J.,Cheng, C.Y.,Saldanha, A.S.,Wu, J.,Cottam, H.,Sankaran, B.,Taylor, S.S. (deposition date: 2013-03-25, release date: 2013-09-18, Last modification date: 2023-09-20) |
Primary citation | Brown, S.H.,Cheng, C.Y.,Saldanha, S.A.,Wu, J.,Cottam, H.B.,Sankaran, B.,Taylor, S.S. Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs. Acs Chem.Biol., 8:2164-2172, 2013 Cited by PubMed: 23978166DOI: 10.1021/cb400247t PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.952 Å) |
Structure validation
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