7XE3
| Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) | Descriptor: | 1,2-ETHANEDIOL, 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal, CITRATE ANION, ... | Authors: | Niwa, H, Sato, S, Umehara, T. | Deposit date: | 2022-03-29 | Release date: | 2022-09-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
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7E9M
| Crystal Structure of Spindlin1 bound to SPINDOC Docpep3 | Descriptor: | Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 | Authors: | Zhao, F, Li, H. | Deposit date: | 2021-03-04 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
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7EA1
| Crystal Structure of Spindlin1 bound to SPINDOC Docpep2 | Descriptor: | Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 | Authors: | Zhao, F, Li, H. | Deposit date: | 2021-03-05 | Release date: | 2022-06-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
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7ZEX
| Complex Cyp33-RRMdelta alpha : UAAUGUCG RNA | Descriptor: | Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, RNA (5'-R(*UP*AP*AP*UP*GP*UP*CP*G)-3') | Authors: | Blatter, M, Allain, F, Meylan, C. | Deposit date: | 2022-03-31 | Release date: | 2022-05-04 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
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7OCB
| Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[3-(1,3-dihydroisoindol-2-yl)propoxy]-2N-[2-(dimethylamino)ethyl]-6-methoxy-4N-(1-propan-2-ylpiperidin-4-yl)quinazoline-2,4-diamine, CHLORIDE ION, ... | Authors: | Johansson, C, Krojer, T, Park, K, Xiong, Y, Jin, J, Oppermann, U. | Deposit date: | 2021-04-26 | Release date: | 2022-05-04 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B To Be Published
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7ZEW
| Complex Cyp33-RRM : AAUAAA RNA | Descriptor: | Peptidyl-prolyl cis-trans isomerase E, RNA (5'-R(*AP*AP*UP*AP*AP*A)-3') | Authors: | Blatter, M, Allain, F, Meylan, C. | Deposit date: | 2022-03-31 | Release date: | 2022-04-13 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
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7ZEZ
| Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3 | Descriptor: | Histone H3, Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, MLL cleavage product N320, ... | Authors: | Blatter, M, Allain, F, Meylan, C. | Deposit date: | 2022-03-31 | Release date: | 2022-04-13 | Last modified: | 2023-05-03 | Method: | SOLUTION NMR | Cite: | RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
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7ZEY
| Complex Cyp33-RRM : MLL1-PHD3 | Descriptor: | MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION | Authors: | Blatter, M, Allain, F, Meylan, C. | Deposit date: | 2022-03-31 | Release date: | 2022-04-13 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
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7ZEV
| Free form of extended Cyp33-RRM | Descriptor: | Peptidyl-prolyl cis-trans isomerase E | Authors: | Blatter, M, Allain, F, Meylan, C. | Deposit date: | 2022-03-31 | Release date: | 2022-04-13 | Last modified: | 2024-06-19 | Method: | SOLUTION NMR | Cite: | RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
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7BED
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7BCY
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6TUY
| Human LSD1/CoREST bound to the quinazoline inhibitor MC4106 | Descriptor: | CHLORIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Mattevi, A, Marrocco, B. | Deposit date: | 2020-01-08 | Release date: | 2021-07-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237, 2022
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7CFP
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7CFQ
| Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... | Authors: | Zhao, J, Zhang, X, Zang, J. | Deposit date: | 2020-06-27 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
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7M10
| PHF2 PHD Domain Complexed with Peptide From N-terminus of VRK1 | Descriptor: | FORMIC ACID, Lysine-specific demethylase PHF2, Serine/threonine-protein kinase VRK1 N-terminus peptide, ... | Authors: | Horton, J.R, Cheng, X. | Deposit date: | 2021-03-11 | Release date: | 2021-05-26 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. Biochem.J., 478, 2021
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6W5N
| Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) | Descriptor: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | Deposit date: | 2020-03-13 | Release date: | 2021-03-31 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
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6W5I
| Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) | Descriptor: | DNA (147-MER), Histone H2A, Histone H2B 1.1, ... | Authors: | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | Deposit date: | 2020-03-13 | Release date: | 2021-03-31 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (6.9 Å) | Cite: | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
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6W5M
| Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) | Descriptor: | DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. | Deposit date: | 2020-03-13 | Release date: | 2021-03-31 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
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6WKR
| PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome | Descriptor: | DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. | Deposit date: | 2020-04-16 | Release date: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
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6LUK
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6LUI
| Crystal structure of the SAMD1 WH domain and DNA complex | Descriptor: | Atherin, DNA (5'-D(*AP*CP*CP*TP*GP*CP*GP*CP*AP*CP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*GP*GP*TP*GP*CP*GP*CP*AP*GP*GP*T)-3') | Authors: | Zhou, Y, Cao, Y, Wang, Z. | Deposit date: | 2020-01-29 | Release date: | 2021-02-03 | Last modified: | 2021-07-07 | Method: | X-RAY DIFFRACTION (1.781 Å) | Cite: | The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
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6LUJ
| Crystal structure of the SAMD1 SAM domain | Descriptor: | Atherin, SULFATE ION | Authors: | Cao, Y, Zhou, Y, Wang, Z. | Deposit date: | 2020-01-29 | Release date: | 2021-02-03 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.12 Å) | Cite: | The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
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7CNA
| Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide | Descriptor: | ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY, ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR, BENZAMIDINE, ... | Authors: | Qian, C.M. | Deposit date: | 2020-07-30 | Release date: | 2021-01-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation. Nat Commun, 12, 2021
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6L87
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7K7T
| Crystal structure of human MORC4 ATPase-CW in complex with AMPPNP | Descriptor: | Isoform 3 of MORC family CW-type zinc finger protein 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Klein, B.J, Tencer, A.H, Kutateladze, T.G. | Deposit date: | 2020-09-24 | Release date: | 2020-11-11 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Molecular mechanism of the MORC4 ATPase activation. Nat Commun, 11, 2020
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