7ZEZ
Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3
Summary for 7ZEZ
Entry DOI | 10.2210/pdb7zez/pdb |
Related | 7ZEV 7ZEW 7ZEX 7ZEY |
NMR Information | BMRB: 34728 |
Descriptor | Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, MLL cleavage product N320, Histone H3, ... (4 entities in total) |
Functional Keywords | rrm, rna binding protein-structural protein complex, histone 3, h3k4me3, epigenetic, mll1 transcription regulation, infant leukemia, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 19325.52 |
Authors | Blatter, M.,Allain, F.,Meylan, C. (deposition date: 2022-03-31, release date: 2022-04-13, Last modification date: 2023-05-03) |
Primary citation | Blatter, M.,Meylan, C.,Clery, A.,Giambruno, R.,Nikolaev, Y.,Heidecker, M.,Solanki, J.A.,Diaz, M.O.,Gabellini, D.,Allain, F.H. RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9:eadf5330-eadf5330, 2023 Cited by PubMed: 37075125DOI: 10.1126/sciadv.adf5330 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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