6VWA
 
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8STE
 | | Cryo-EM structure of NKCC1 Fu_CTD | | Descriptor: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2023-05-10 | | Release date: | 2023-05-17 | | Last modified: | 2024-06-19 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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6VW9
 | | C-terminal regulatory domain of the chloride transporter KCC-1 from C. elegans, proteolyzed during crystallization | | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, GLYCEROL, K+/Cl-Cotransporter | | Authors: | Zimanyi, C.M, Cheung, J. | | Deposit date: | 2020-02-19 | | Release date: | 2020-07-15 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.
Structure, 28, 2020
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6NPJ
 | | Structure of the NKCC1 CTD | | Descriptor: | Sodium-potassium-chloride cotransporter 1 | | Authors: | Feng, L, Liao, M.F, Orlando, B, Zhang, J.R. | | Deposit date: | 2019-01-17 | | Release date: | 2019-07-31 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure and mechanism of the cation-chloride cotransporter NKCC1.
Nature, 572, 2019
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9BWT
 | | human sodium chloride cotransporter NCC S344E in the phosphorylation state and in complex with hydrochlorothiazide | | Descriptor: | 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | | Authors: | Cao, E.H, Zhao, Y.X. | | Deposit date: | 2024-05-21 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.5 Å) | | Cite: | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Nat Commun, 15, 2024
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6Y5R
 | | Structure of Human Potassium Chloride Transporter KCC3 S45D/T940D/T997D in NaCl | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, B, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L, Structural Genomics Consortium (SGC) | | Deposit date: | 2020-02-25 | | Release date: | 2020-03-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.76 Å) | | Cite: | Structure of Human Potassium Chloride Transporter KCC3 in NaCl
To be published
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6PZT
 | | cryo-EM structure of human NKCC1 | | Descriptor: | Solute carrier family 12 member 2 | | Authors: | Cao, E, Wang, Q, Yang, X. | | Deposit date: | 2019-08-01 | | Release date: | 2020-03-25 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structure of the human cation-chloride cotransporter NKCC1 determined by single-particle electron cryo-microscopy.
Nat Commun, 11, 2020
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6UKN
 | | Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs | | Descriptor: | CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 7, ... | | Authors: | Reid, M.S, Kern, D.M, Brohawn, S.G. | | Deposit date: | 2019-10-05 | | Release date: | 2020-06-10 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs.
Elife, 9, 2020
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7ZGO
 | | Cryo-EM structure of human NKCC1 (TM domain) | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHLORIDE ION, CHOLESTEROL HEMISUCCINATE, ... | | Authors: | Nissen, P, Fenton, R, Neumann, C, Lindtoft Rosenbaek, L, Kock Flygaard, R, Habeck, M, Lykkegaard Karlsen, J, Wang, Y, Lindorff-Larsen, K, Gad, H, Hartmann, R, Lyons, J. | | Deposit date: | 2022-04-04 | | Release date: | 2022-10-05 | | Last modified: | 2023-04-19 | | Method: | ELECTRON MICROSCOPY (2.55 Å) | | Cite: | Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity.
Embo J., 41, 2022
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8VPN
 | | Phosphorylated human NCC in complex with indapamide | | Descriptor: | 4-chloro-N-[(2S)-2-methyl-2,3-dihydro-1H-indol-1-yl]-3-sulfamoylbenzamide, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 3 | | Authors: | Zhao, Y.X, Cao, E.H. | | Deposit date: | 2024-01-16 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Nat Commun, 15, 2024
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8VPP
 | | Phosphorylated human NCC in complex with chlorthalidone | | Descriptor: | 2-chloro-5-[(1S)-1-hydroxy-3-oxo-2H-isoindol-1-yl]benzenesulfonamide, Solute carrier family 12 member 3 | | Authors: | Zhao, Y.X, Cao, E.H. | | Deposit date: | 2024-01-16 | | Release date: | 2024-09-04 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structural bases for Na + -Cl - cotransporter inhibition by thiazide diuretic drugs and activation by kinases.
Nat Commun, 15, 2024
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6NPL
 | | Cryo-EM structure of NKCC1 | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHLORIDE ION, POTASSIUM ION, ... | | Authors: | Feng, L, Liao, M.F, Orlando, B, Zhang, J.R. | | Deposit date: | 2019-01-17 | | Release date: | 2019-07-31 | | Last modified: | 2019-08-28 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structure and mechanism of the cation-chloride cotransporter NKCC1.
Nature, 572, 2019
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6Y5V
 | | Structure of Human Potassium Chloride Transporter KCC3b (S45D/T940D/T997D) in KCl | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Chi, G, Man, H, Ebenhoch, R, Reggiano, G, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, DiMaio, F, Duerr, K.L. | | Deposit date: | 2020-02-25 | | Release date: | 2020-07-15 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (4.08 Å) | | Cite: | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
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7TTI
 | | Human KCC1 bound with VU0463271 In an outward-open state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenylpyridazin-3-yl)sulfanyl]acetamide, Solute carrier family 12 member 4 | | Authors: | Zhao, Y.X, Cao, E.H. | | Deposit date: | 2022-02-01 | | Release date: | 2022-06-29 | | Last modified: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7TTH
 | | Human potassium-chloride cotransporter 1 in inward-open state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, POTASSIUM ION, Solute carrier family 12 member 4 | | Authors: | Zhao, Y.X, Cao, E.H. | | Deposit date: | 2022-02-01 | | Release date: | 2022-06-29 | | Last modified: | 2022-07-13 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Structure of the human cation-chloride cotransport KCC1 in an outward-open state.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SMP
 | | CryoEM structure of NKCC1 Bu-I | | Descriptor: | 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid, POTASSIUM ION, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2021-10-26 | | Release date: | 2022-09-28 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3.28 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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7NGB
 | | Structure of Wild-Type Human Potassium Chloride Transporter KCC3 in NaCl (LMNG/CHS) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Isoform 2 of Solute carrier family 12 member 6, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Chi, G, Man, H, Pike, A.C.W, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Abrusci, P, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L. | | Deposit date: | 2021-02-09 | | Release date: | 2021-06-09 | | Last modified: | 2021-07-28 | | Method: | ELECTRON MICROSCOPY (3.64 Å) | | Cite: | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters.
Embo J., 40, 2021
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7MXO
 | | CryoEM structure of human NKCC1 | | Descriptor: | CHLORIDE ION, POTASSIUM ION, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2021-05-19 | | Release date: | 2022-09-28 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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7N3N
 | | CryoEM structure of human NKCC1 state Fu-I | | Descriptor: | 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID, Solute carrier family 12 member 2 | | Authors: | Moseng, M.A. | | Deposit date: | 2021-06-01 | | Release date: | 2022-09-28 | | Last modified: | 2023-05-31 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.
Sci Adv, 8, 2022
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7YG1
 | | Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter | | Descriptor: | Solute carrier family 12 member 3 | | Authors: | Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q. | | Deposit date: | 2022-07-09 | | Release date: | 2022-11-23 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.77 Å) | | Cite: | Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
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7YG0
 | | Cryo-EM structure of human sodium-chloride cotransporter | | Descriptor: | Solute carrier family 12 member 3 | | Authors: | Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q. | | Deposit date: | 2022-07-09 | | Release date: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
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7Y6I
 | | Cryo-EM structure of human sodium-chloride cotransporter | | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Nan, J, Yang, X, Shan, Z, Yuan, Y, Zhang, Y.Q. | | Deposit date: | 2022-06-20 | | Release date: | 2022-11-23 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Cryo-EM structure of the human sodium-chloride cotransporter NCC.
Sci Adv, 8, 2022
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7S1X
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7S1Z
 | | Cryo-EM structure of Human NKCC1 K289NA492EL671C | | Descriptor: | Solute carrier family 12 member 2 | | Authors: | Zhao, Y.X, Cao, E.H. | | Deposit date: | 2021-09-02 | | Release date: | 2022-05-25 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis for inhibition of the Cation-chloride cotransporter NKCC1 by the diuretic drug bumetanide
Nat Commun, 13, 2022
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7S1Y
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