7N3N

CryoEM structure of human NKCC1 state Fu-I

Summary for 7N3N

• Entry DOI: 10.2210/pdb7n3n/pdb
• EMDB information: 24141
• Descriptor: Solute carrier family 12 member 2, 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID (2 entities in total)
• Functional Keywords: sodium, potassium, chloride, co-transporter, ions, human, ctd, tmd, full-length, membrane protein, furosemide, diuretic, loop diuretic
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 263828.33

Authors

Moseng, M.A. (deposition date: 2021-06-01, release date: 2022-09-28, Last modification date: 2023-05-31)

• Primary citation: Moseng, M.A.,Su, C.C.,Rios, K.,Cui, M.,Lyu, M.,Glaza, P.,Klenotic, P.A.,Delpire, E.,Yu, E.W.; Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.; Sci Adv, 8:eabq0952-eabq0952, 2022; PubMed: 36306358; DOI: 10.1126/sciadv.abq0952

Experimental method

ELECTRON MICROSCOPY (3.33 Å)