8STE

Cryo-EM structure of NKCC1 Fu_CTD

Summary for 8STE

• Entry DOI: 10.2210/pdb8ste/pdb
• EMDB information: 40759
• Descriptor: Solute carrier family 12 member 2, 5-(AMINOSULFONYL)-4-CHLORO-2-[(2-FURYLMETHYL)AMINO]BENZOIC ACID (2 entities in total)
• Functional Keywords: cotransporter, dimer, ion, membrane protein, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 91042.36

Authors

Moseng, M.A. (deposition date: 2023-05-10, release date: 2023-05-17, Last modification date: 2023-05-31)

• Primary citation: Moseng, M.A.,Su, C.C.,Rios, K.,Cui, M.,Lyu, M.,Glaza, P.,Klenotic, P.A.,Delpire, E.,Yu, E.W.; Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling.; Sci Adv, 8:eabq0952-, 2022; PubMed: 36306358; DOI: 10.1126/sciadv.abq0952

Experimental method

ELECTRON MICROSCOPY (3.34 Å)