7ZGO

Cryo-EM structure of human NKCC1 (TM domain)

Summary for 7ZGO

Entry DOI	10.2210/pdb7zgo/pdb
EMDB information	14709
Descriptor	Solute carrier family 12 member 2, SODIUM ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywords	slc12 family, nkcc1 in complex with na+, k+ and 2cl-, leut-fold, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	272146.13
Authors	Nissen, P.,Fenton, R.,Neumann, C.,Lindtoft Rosenbaek, L.,Kock Flygaard, R.,Habeck, M.,Lykkegaard Karlsen, J.,Wang, Y.,Lindorff-Larsen, K.,Gad, H.,Hartmann, R.,Lyons, J. (deposition date: 2022-04-04, release date: 2022-10-05, Last modification date: 2023-04-19)
Primary citation	Neumann, C.,Rosenbaek, L.L.,Flygaard, R.K.,Habeck, M.,Karlsen, J.L.,Wang, Y.,Lindorff-Larsen, K.,Gad, H.H.,Hartmann, R.,Lyons, J.A.,Fenton, R.A.,Nissen, P. Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity. Embo J., 41:e110169-e110169, 2022 Cited by PubMed: 36239040 DOI: 10.15252/embj.2021110169 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.55 Å)

Structure validation