7ZGO
Cryo-EM structure of human NKCC1 (TM domain)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Solute carrier family 12 member 2 | polymer | 1216 | 131819.6 | 2 | UniProt (P55011) Pfam (PF08403) Pfam (PF00324) Pfam (PF03522) | Homo sapiens (human) | Basolateral Na-K-Cl symporter,Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 |
| 2 | C, N (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 3 | D, O (A, B) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 4 | E, F, P, Q (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 5 | G, H, I, J, R... (A, B) | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 7 | Chemie (POV) | |||
| 6 | K, L, M, U, V... (A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 6 | Chemie (Y01) | |||
| 7 | X, Y (A, B) | water | water | 18.0 | 24 | Chemie (HOH) |
Sequence modifications
A, B: 2 - 1212 (UniProt: P55011)
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ala 0 | - | expression tag |
| Ala 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 263639.3 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 8506.9 | |
| All* | Total formula weight | 272146.1 |
