Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2LBD
DownloadVisualize
BU of 2lbd by Molmil
LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID
Descriptor: RETINOIC ACID, RETINOIC ACID RECEPTOR GAMMA
Authors:Renaud, J.-P, Rochel, N, Ruff, M, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:1997-08-19
Release date:1997-11-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
Nature, 378, 1995
5FQR
DownloadVisualize
BU of 5fqr by Molmil
Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 2.
Descriptor: (E)-3-[4-[(1R)-6-HYDROXY-2-ISOBUTYL-3,4-DIHYDRO-1H-ISOQUINOLIN-1-YL]PHENYL]PROP-2-ENOIC ACID, ESTROGEN RECEPTOR
Authors:Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D.
Deposit date:2015-12-14
Release date:2016-02-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
Acs Med.Chem.Lett., 7, 2016
1H9U
DownloadVisualize
BU of 1h9u by Molmil
The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268
Descriptor: 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, NICKEL (II) ION, ...
Authors:Schwabe, J.W.R, Love, J.D, Gooch, J.T.
Deposit date:2001-03-21
Release date:2002-04-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12
J.Biol.Chem., 277, 2002
2XHS
DownloadVisualize
BU of 2xhs by Molmil
Crystal structure of the ligand binding domain of Fushi tarazu factor 1 of Drosophila melanogaster.
Descriptor: NUCLEAR HORMONE RECEPTOR FTZ-F1, SEGMENTATION PROTEIN FUSHI TARAZU
Authors:Yoo, J.H, Cho, H.S.
Deposit date:2010-06-21
Release date:2011-07-20
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Fushi Tarazu Factor 1 Ligand Binding Domain/Fushi Tarazu Peptide Complex Identifies New Class of Nuclear Receptors.
J.Biol.Chem., 286, 2011
4CI4
DownloadVisualize
BU of 4ci4 by Molmil
Structural basis for GL479 a dual Peroxisome Proliferator-Activated Receptor alpha agonist
Descriptor: 2-methyl-2-[4-[2-[4-[(E)-phenyldiazenyl]phenoxy]ethyl]phenoxy]propanoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA
Authors:Santos, J.C, Bernardes, A, Polikarpov, I.
Deposit date:2013-12-05
Release date:2014-12-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Different binding and recognition modes of GL479, a dual agonist of Peroxisome Proliferator-Activated Receptor alpha / gamma.
J. Struct. Biol., 191, 2015
5FQS
DownloadVisualize
BU of 5fqs by Molmil
Selective estrogen receptor downregulator antagonists: Tetrahydroisoquinoline phenols 3.
Descriptor: (E)-3-[4-(6-HYDROXY-2-ISOBUTYL-1-METHYL-3,4-DIHYDROISOQUINOLIN-1-YL)PHENYL]PROP-2-ENOIC ACID, ESTROGEN RECEPTOR
Authors:Scott, J.S, Bailey, A, Davies, R.D.M, Degorce, S.L, MacFaul, P.A, Gingell, H, Moss, T, Norman, R.A, Pink, J.H, Rabow, A.A, Roberts, B, Smith, P.D.
Deposit date:2015-12-14
Release date:2016-02-10
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat.
Acs Med.Chem.Lett., 7, 2016
1GWR
DownloadVisualize
BU of 1gwr by Molmil
HUMAN OESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 17BETA-OESTRADIOL AND TIF2 NRBOX3 PEPTIDE
Descriptor: ESTRADIOL, OESTROGEN RECEPTOR, TRANSCRIPTION INTERMEDIARY FACTOR-2
Authors:Pike, A.C.W, Brzozowski, A.M.
Deposit date:2002-03-22
Release date:2002-08-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Interaction of Transcriptional Intermediary Factor 2 Nuclear Receptor Box Peptides with the Coactivator Binding Site of Estrogen Receptor Alpha.
J.Biol.Chem., 277, 2002
4CSJ
DownloadVisualize
BU of 4csj by Molmil
The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation
Descriptor: 1,2-ETHANEDIOL, GLUCOCORTICOID RECEPTOR, N-[(2S)-1-[[1-(4-fluorophenyl)indazol-4-yl]amino]propan-2-yl]-2,4,6-trimethyl-benzenesulfonamide, ...
Authors:Edman, K, Ahlgren, R, Bengtsson, M, Bladh, H, Backstrom, S, Dahmen, J, Henriksson, K, Hillertz, P, Hulikal, V, Jerre, A, Kinchin, L, Kase, C, Lepisto, M, Mile, I, Nilsson, S, Smailagic, A, Taylor, J, Tjornebo, A, Wissler, L, Hansson, T.
Deposit date:2014-03-07
Release date:2014-05-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation.
Bioorg.Med.Chem.Lett., 24, 2014
2XYJ
DownloadVisualize
BU of 2xyj by Molmil
Novel Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (PPAR) gamma-delta Agonists with High Potency and In-vivo Efficacy
Descriptor: 5-CHLORO-2-METHOXY-N-[2-[4-[(5-PROPAN-2-YL-1,3,4-THIADIAZOL-2-YL)SULFAMOYL]PHENYL]ETHYL]BENZAMIDE, PENTAETHYLENE GLYCOL, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR DELTA
Authors:Marquette, J.-P, Mathieu, M.
Deposit date:2010-11-18
Release date:2011-02-23
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Sulfonylthiadiazoles with an Unusual Binding Mode as Partial Dual Peroxisome Proliferator-Activated Receptor (Ppar) Gamma / Delta Agonists with High Potency and in-Vivo Efficacy
Chemmedchem, 6, 2011
1QKT
DownloadVisualize
BU of 1qkt by Molmil
MUTANT ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL
Descriptor: ESTRADIOL, ESTRADIOL RECEPTOR
Authors:Ruff, M, Gangloff, M, Eiler, S, Duclaud, S, Wurtz, J.M, Moras, D.
Deposit date:1999-08-05
Release date:2000-08-18
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Mutant Heralpha Ligand- Binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
J.Biol.Chem., 276, 2001
1QKN
DownloadVisualize
BU of 1qkn by Molmil
RAT OESTROGEN RECEPTOR BETA LIGAND-BINDING DOMAIN IN COMPLEX WITH ANTAGONIST RALOXIFENE
Descriptor: ACETATE ION, ESTROGEN RECEPTOR BETA, RALOXIFENE
Authors:Pike, A.C.W, Brzozowski, A.M, Carlquist, M.
Deposit date:1999-07-27
Release date:2000-07-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Ligand-Binding Domain of Oestrogen Receptor Beta in the Presence of a Partial Agonist and a Full Antagonist
Embo J., 18, 1999
6EL7
DownloadVisualize
BU of 6el7 by Molmil
Glucocorticoid Receptor in complex with compound 31
Descriptor: 1,2-ETHANEDIOL, Glucocorticoid receptor, Nuclear receptor coactivator 2, ...
Authors:Edman, K, Wissler, L.
Deposit date:2017-09-28
Release date:2018-02-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Discovery of a Novel Oral Glucocorticoid Receptor Modulator (AZD9567) with Improved Side Effect Profile.
J. Med. Chem., 61, 2018
1A28
DownloadVisualize
BU of 1a28 by Molmil
HORMONE-BOUND HUMAN PROGESTERONE RECEPTOR LIGAND-BINDING DOMAIN
Descriptor: PROGESTERONE, PROGESTERONE RECEPTOR
Authors:Sigler, P.B, Williams, S.P.
Deposit date:1998-01-19
Release date:1998-07-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Atomic structure of progesterone complexed with its receptor.
Nature, 393, 1998
6EU9
DownloadVisualize
BU of 6eu9 by Molmil
Crystal structure of Platynereis dumerilii RAR ligand-binding domain in complex with all-trans retinoic acid
Descriptor: RETINOIC ACID, Retinoic acid receptor
Authors:Handberg-Thorsager, M, Gutierrez-Mazariegos, J, Arold, S.T, Nadendla, E.K, Bertucci, P.Y, Germain, P, Tomancak, P, Pierzchalski, K, Jones, J.W, Albalat, R, Kane, M.A, Bourguet, W, Laudet, V, Arendt, D, Schubert, M.
Deposit date:2017-10-29
Release date:2018-03-14
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation.
Sci Adv, 4, 2018
6ESN
DownloadVisualize
BU of 6esn by Molmil
Ligand complex of RORg LBD
Descriptor: (2~{R})-2-acetamido-~{N}-[4-(5-cyano-3-fluoranyl-2-methoxy-phenyl)thiophen-2-yl]-2-(4-ethylsulfonylphenyl)ethanamide, LYS-HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER, Nuclear receptor ROR-gamma, ...
Authors:Xue, Y, Aagaard, A, Narjes, F.
Deposit date:2017-10-23
Release date:2018-08-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Potent and Orally Bioavailable Inverse Agonists of ROR gamma t Resulting from Structure-Based Design.
J. Med. Chem., 61, 2018
1A52
DownloadVisualize
BU of 1a52 by Molmil
ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO ESTRADIOL
Descriptor: ESTRADIOL, ESTROGEN RECEPTOR, GOLD ION
Authors:Tanenbaum, D.M, Wang, Y, Sigler, P.B.
Deposit date:1998-02-19
Release date:1998-09-16
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains.
Proc.Natl.Acad.Sci.USA, 95, 1998
1BSX
DownloadVisualize
BU of 1bsx by Molmil
STRUCTURE AND SPECIFICITY OF NUCLEAR RECEPTOR-COACTIVATOR INTERACTIONS
Descriptor: 3,5,3'TRIIODOTHYRONINE, PROTEIN (GRIP1), PROTEIN (THYROID HORMONE RECEPTOR BETA)
Authors:Wagner, R.L, Darimont, B.D, Apriletti, J.W, Stallcup, M.R, Kushner, P.J, Baxter, J.D, Fletterick, R.J, Yamamoto, K.R.
Deposit date:1998-08-31
Release date:1999-08-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure and specificity of nuclear receptor-coactivator interactions.
Genes Dev., 12, 1998
6VQF
DownloadVisualize
BU of 6vqf by Molmil
CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244- 487)-L6-SRC1(678-692)) IN COMPLEX WITH AN INVERSE AGONIST
Descriptor: (1R,3S,4R)-4-[(3aR,9bR)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl]-3-methylcyclohexane-1-carboxylic acid, GLYCEROL, Nuclear receptor ROR-gamma
Authors:Sack, J.S.
Deposit date:2020-02-05
Release date:2020-04-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR gamma t Inverse Agonist.
Acs Med.Chem.Lett., 11, 2020
5M24
DownloadVisualize
BU of 5m24 by Molmil
RARg mutant-S371E
Descriptor: (9cis)-retinoic acid, CHLORIDE ION, DODECYL-ALPHA-D-MALTOSIDE, ...
Authors:Rochel, N, Sirigu, S.
Deposit date:2016-10-11
Release date:2017-09-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptor gamma.
PLoS ONE, 12, 2017
4LNW
DownloadVisualize
BU of 4lnw by Molmil
Crystal structure of TR-alpha bound to T3 in a second site
Descriptor: 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor alpha
Authors:Puhl, A.C, Aparicio, R, Polikarpov, I.
Deposit date:2013-07-12
Release date:2014-03-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Identification of a new hormone-binding site on the surface of thyroid hormone receptor.
Mol.Endocrinol., 28, 2014
6P2B
DownloadVisualize
BU of 6p2b by Molmil
Tethered PXR-LBD/SRC-1p bound to Garcinoic Acid
Descriptor: (2Z,6E,10E)-13-[(2R)-6-hydroxy-2,8-dimethyl-3,4-dihydro-2H-1-benzopyran-2-yl]-2,6,10-trimethyltrideca-2,6,10-trienoic acid, DIMETHYL SULFOXIDE, Nuclear receptor subfamily 1 group I member 2
Authors:Walton, W.G, Pellock, S.J, Redinbo, M.R.
Deposit date:2019-05-21
Release date:2020-04-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor.
J.Med.Chem., 63, 2020
6VPF
DownloadVisualize
BU of 6vpf by Molmil
Estrogen Receptor Alpha Ligand Binding Domain in Complex with the Selective Estrogen Receptor Modulator Clomiphene
Descriptor: Clomifene, Estrogen receptor
Authors:Fanning, S.W, Greene, G.L.
Deposit date:2020-02-03
Release date:2020-09-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells.
Elife, 11, 2022
6VIF
DownloadVisualize
BU of 6vif by Molmil
Human LRH-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator TIF-2
Descriptor: N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6:7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric diamide, Nuclear receptor coactivator 2, Nuclear receptor subfamily 5 group A member 2
Authors:Cato, M.L, Ortlund, E.A.
Deposit date:2020-01-13
Release date:2020-06-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition.
Bioorg.Med.Chem.Lett., 30, 2020
5MKJ
DownloadVisualize
BU of 5mkj by Molmil
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 9 and a fragment of the TIF2 co-activator.
Descriptor: (~{E})-3-[4-oxidanyl-3-(5-prop-2-enyl-2-propoxy-phenyl)phenyl]prop-2-enoic acid, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, Retinoic acid receptor RXR-alpha
Authors:Andrei, S.A, Brunsveld, L, Scheepstra, M, Ottmann, C.
Deposit date:2016-12-05
Release date:2017-11-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
ACS Chem Neurosci, 8, 2017
4LNX
DownloadVisualize
BU of 4lnx by Molmil
Crystal structure of TR-alpha bound to T4 in a second site
Descriptor: 3,5,3',5'-TETRAIODO-L-THYRONINE, 3,5,3'TRIIODOTHYRONINE, Thyroid hormone receptor alpha
Authors:Puhl, A.C, Aparicio, R, Polikarpov, I.
Deposit date:2013-07-12
Release date:2014-03-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Identification of a new hormone-binding site on the surface of thyroid hormone receptor.
Mol.Endocrinol., 28, 2014

225158

數據於2024-09-18公開中

PDB statisticsPDBj update infoContact PDBjnumon