6VQF

CRYSTAL STRUCTURE OF RAR-RELATED ORPHAN RECEPTOR C (NHIS-RORGT(244- 487)-L6-SRC1(678-692)) IN COMPLEX WITH AN INVERSE AGONIST

Summary for 6VQF

Entry DOI	10.2210/pdb6vqf/pdb
Descriptor	Nuclear receptor ROR-gamma, (1R,3S,4R)-4-[(3aR,9bR)-9b-[(4-fluorophenyl)sulfonyl]-7-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)-1,2,3a,4,5,9b-hexahydro-3H-benzo[e]indole-3-carbonyl]-3-methylcyclohexane-1-carboxylic acid, GLYCEROL, ... (4 entities in total)
Functional Keywords	rorgt, nuclear hormone receptor, ligand-binding domain, inverse agonist, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33646.62
Authors	Sack, J.S. (deposition date: 2020-02-05, release date: 2020-04-08, Last modification date: 2023-10-11)
Primary citation	Cherney, R.J.,Cornelius, L.A.M.,Srivastava, A.,Weigelt, C.A.,Marcoux, D.,Duan, J.J.,Shi, Q.,Batt, D.G.,Liu, Q.,Yip, S.,Wu, D.R.,Ruzanov, M.,Sack, J.,Khan, J.,Wang, J.,Yarde, M.,Cvijic, M.E.,Mathur, A.,Li, S.,Shuster, D.,Khandelwal, P.,Borowski, V.,Xie, J.,Obermeier, M.,Fura, A.,Stefanski, K.,Cornelius, G.,Tino, J.A.,Macor, J.E.,Salter-Cid, L.,Denton, R.,Zhao, Q.,Carter, P.H.,Dhar, T.G.M. Discovery of BMS-986251: A Clinically Viable, Potent, and Selective ROR gamma t Inverse Agonist. Acs Med.Chem.Lett., 11:1221-1227, 2020 Cited by PubMed: 32551004 DOI: 10.1021/acsmedchemlett.0c00063 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation