4CSJ

The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation

Summary for 4CSJ

DescriptorGLUCOCORTICOID RECEPTOR, NUCLEAR RECEPTOR COACTIVATOR 2, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordssignaling protein, nuclear hormone receptor, ligand complex, peptide complex
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm. Isoform Beta: Nucleus P04150
Total number of polymer chains2
Total molecular weight34295.53
Authors
Primary citation
Edman, K.,Ahlgren, R.,Bengtsson, M.,Bladh, H.,Backstrom, S.,Dahmen, J.,Henriksson, K.,Hillertz, P.,Hulikal, V.,Jerre, A.,Kinchin, L.,Kase, C.,Lepisto, M.,Mile, I.,Nilsson, S.,Smailagic, A.,Taylor, J.,Tjornebo, A.,Wissler, L.,Hansson, T.
The Discovery of Potent and Selective Non-Steroidal Glucocorticoid Receptor Modulators, Suitable for Inhalation.
Bioorg.Med.Chem.Lett., 24:2571-, 2014
PubMed: 24755427 (PDB entries with the same primary citation)
DOI: 10.1016/J.BMCL.2014.03.070
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.3 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.225200.8%3.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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