4CSJ
The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | GLUCOCORTICOID RECEPTOR | polymer | 280 | 32187.1 | 1 | UniProt (P04150) Pfam (PF00104) | HOMO SAPIENS (HUMAN) | GR, NUCLEAR RECEPTOR SUBFAMILY 3 GROUP C MEMBER 1 |
| 2 | B (B) | NUCLEAR RECEPTOR COACTIVATOR 2 | polymer | 13 | 1579.8 | 1 | UniProt (E7EWM1) UniProt (by SIFTS) (Q15596) | HOMO SAPIENS (HUMAN) | |
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | N-[(2S)-1-[[1-(4-fluorophenyl)indazol-4-yl]amino]propan-2-yl]-2,4,6-trimethyl-benzenesulfonamide | non-polymer | 466.6 | 1 | Chemie (NN7) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 99 | Chemie (HOH) |
Sequence modifications
A: 500 - 777 (UniProt: P04150)
| PDB | External Database | Details |
|---|---|---|
| Gly 498 | - | expression tag |
| Ser 499 | - | expression tag |
| Asp 517 | Asn 517 | engineered mutation |
| Met 571 | Val 571 | engineered mutation |
| Ser 602 | Phe 602 | engineered mutation |
| Asp 638 | Cys 638 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33766.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 528.6 | |
| All* | Total formula weight | 34295.5 |
