4LNX

Crystal structure of TR-alpha bound to T4 in a second site

Summary for 4LNX

Entry DOI	10.2210/pdb4lnx/pdb
Related	3ILZ 3JZB 4LNW
Descriptor	Thyroid hormone receptor alpha, 3,5,3',5'-TETRAIODO-L-THYRONINE, 3,5,3'TRIIODOTHYRONINE, ... (4 entities in total)
Functional Keywords	mainly alpha orthogonal bundle, transcription factor, transcription
Biological source	Homo sapiens (human)
Cellular location	Nucleus: P10827
Total number of polymer chains	1
Total formula weight	32205.79
Authors	Puhl, A.C.,Aparicio, R.,Polikarpov, I. (deposition date: 2013-07-12, release date: 2014-03-19, Last modification date: 2023-11-15)
Primary citation	Souza, P.C.,Puhl, A.C.,Martinez, L.,Aparicio, R.,Nascimento, A.S.,Figueira, A.C.,Nguyen, P.,Webb, P.,Skaf, M.S.,Polikarpov, I. Identification of a new hormone-binding site on the surface of thyroid hormone receptor. Mol.Endocrinol., 28:534-545, 2014 Cited by PubMed: 24552590 DOI: 10.1210/me.2013-1359 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation