PDB: 263 件ウェブページステータス検索Chemie searchBIRD

---

7XE3	Crystal structure of LSD2 in complex with cis-4-Br-2,5-F2-PCPA (S1024) 分子名称: 1,2-ETHANEDIOL, 3-[4-bromanyl-2,5-bis(fluoranyl)phenyl]propanal, CITRATE ANION, ... 著者 Niwa, H, Sato, S, Umehara, T. 登録日 2022-03-29 公開日 2022-09-14 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.82 Å) 主引用文献 Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 Acs Med.Chem.Lett., 13, 2022
7E9M	Crystal Structure of Spindlin1 bound to SPINDOC Docpep3 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-04 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
7EA1	Crystal Structure of Spindlin1 bound to SPINDOC Docpep2 分子名称: Peptide from Spindlin interactor and repressor of chromatin-binding protein, Spindlin-1 著者 Zhao, F, Li, H. 登録日 2021-03-05 公開日 2022-06-15 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Molecular basis for SPINDOC-Spindlin1 engagement and its role in transcriptional inhibition to be published
7ZEX	Complex Cyp33-RRMdelta alpha : UAAUGUCG RNA 分子名称: Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, RNA (5'-R(*UP*AP*AP*UP*GP*UP*CP*G)-3') 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-05-04 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7OCB	Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[3-(1,3-dihydroisoindol-2-yl)propoxy]-2N-[2-(dimethylamino)ethyl]-6-methoxy-4N-(1-propan-2-ylpiperidin-4-yl)quinazoline-2,4-diamine, CHLORIDE ION, ... 著者 Johansson, C, Krojer, T, Park, K, Xiong, Y, Jin, J, Oppermann, U. 登録日 2021-04-26 公開日 2022-05-04 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Crystal structure of Spindlin1 in complex with the inhibitor XY49-92B To Be Published
7ZEW	Complex Cyp33-RRM : AAUAAA RNA 分子名称: Peptidyl-prolyl cis-trans isomerase E, RNA (5'-R(*AP*AP*UP*AP*AP*A)-3') 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEZ	Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3 分子名称: Histone H3, Isoform 3 of Peptidyl-prolyl cis-trans isomerase E, MLL cleavage product N320, ... 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2023-05-03 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEY	Complex Cyp33-RRM : MLL1-PHD3 分子名称: MLL cleavage product N320, Peptidyl-prolyl cis-trans isomerase E, ZINC ION 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7ZEV	Free form of extended Cyp33-RRM 分子名称: Peptidyl-prolyl cis-trans isomerase E 著者 Blatter, M, Allain, F, Meylan, C. 登録日 2022-03-31 公開日 2022-04-13 最終更新日 2024-06-19 実験手法 SOLUTION NMR 主引用文献 RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Sci Adv, 9, 2023
7BED	X-ray structure of WDR5 bound to the WDR5 win motif peptide 分子名称: SULFATE ION, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-23 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.26 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
7BCY	X-ray structure of WDR5delta24 bound to the Kaposi's sarcoma herpesvirus LANA win motif peptide 分子名称: ORF 73, WD repeat-containing protein 5 著者 McVey, C.E, Kaye, K.M. 登録日 2020-12-21 公開日 2021-12-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 MLL1 is regulated by KSHV LANA and is important for virus latency. Nucleic Acids Res., 49, 2021
6TUY	Human LSD1/CoREST bound to the quinazoline inhibitor MC4106 分子名称: CHLORIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... 著者 Mattevi, A, Marrocco, B. 登録日 2020-01-08 公開日 2021-07-21 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Novel non-covalent LSD1 inhibitors endowed with anticancer effects in leukemia and solid tumor cellular models. Eur.J.Med.Chem., 237, 2022
7CFP	Crystal structure of WDR5 in complex with a H3Q5ser peptide 分子名称: H3Q5ser peptide, SEROTONIN, WD repeat-containing protein 5 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
7CFQ	Crystal structure of WDR5 in complex with H3K4me3Q5ser peptide 分子名称: 1,2-ETHANEDIOL, GLYCEROL, H3K4me3Q5ser peptide, ... 著者 Zhao, J, Zhang, X, Zang, J. 登録日 2020-06-27 公開日 2021-07-07 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural insights into the recognition of histone H3Q5 serotonylation by WDR5. Sci Adv, 7, 2021
7M10	PHF2 PHD Domain Complexed with Peptide From N-terminus of VRK1 分子名称: FORMIC ACID, Lysine-specific demethylase PHF2, Serine/threonine-protein kinase VRK1 N-terminus peptide, ... 著者 Horton, J.R, Cheng, X. 登録日 2021-03-11 公開日 2021-05-26 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. Biochem.J., 478, 2021
6W5N	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class05) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5I	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class01) 分子名称: DNA (147-MER), Histone H2A, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (6.9 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6W5M	Cryo-EM structure of MLL1 in complex with RbBP5, WDR5, SET1, and ASH2L bound to the nucleosome (Class02) 分子名称: DNA (147-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Park, S.H, Lee, Y.T, Ayoub, A, Dou, Y, Cho, U. 登録日 2020-03-13 公開日 2021-03-31 最終更新日 2024-05-29 実験手法 ELECTRON MICROSCOPY (4.6 Å) 主引用文献 Mechanism for DPY30 and ASH2L intrinsically disordered regions to modulate the MLL/SET1 activity on chromatin. Nat Commun, 12, 2021
6WKR	PRC2-AEBP2-JARID2 bound to H2AK119ub1 nucleosome 分子名称: DNA (314-MER), Histone H2A type 1, Histone H2B 1.1, ... 著者 Kasinath, V, Nogales, E, Beck, C, Sauer, P, Poepsel, S, Kosmatka, J, Faini, M, Toso, D, Aebersold, R. 登録日 2020-04-16 公開日 2021-02-03 実験手法 ELECTRON MICROSCOPY (3.5 Å) 主引用文献 JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications. Science, 371, 2021
6LUK	Crystal structure of the SAMD1 SAM domain in another crystal form 分子名称: Atherin, SULFATE ION 著者 Cao, Y, Zhou, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.054 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6LUI	Crystal structure of the SAMD1 WH domain and DNA complex 分子名称: Atherin, DNA (5'-D(*AP*CP*CP*TP*GP*CP*GP*CP*AP*CP*CP*AP*T)-3'), DNA (5'-D(*AP*TP*GP*GP*TP*GP*CP*GP*CP*AP*GP*GP*T)-3') 著者 Zhou, Y, Cao, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2021-07-07 実験手法 X-RAY DIFFRACTION (1.781 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
6LUJ	Crystal structure of the SAMD1 SAM domain 分子名称: Atherin, SULFATE ION 著者 Cao, Y, Zhou, Y, Wang, Z. 登録日 2020-01-29 公開日 2021-02-03 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.12 Å) 主引用文献 The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv, 7, 2021
7CNA	Crystal structure of Spindlin1/C11orf84 complex bound to histone H3K4me3K9me3 peptide 分子名称: ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-GLY, ALA-ARG-THR-M3L-GLN-THR-ALA-ARG-M3L-SER-THR, BENZAMIDINE, ... 著者 Qian, C.M. 登録日 2020-07-30 公開日 2021-01-13 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structural mechanism of bivalent histone H3K4me3K9me3 recognition by the Spindlin1/C11orf84 complex in rRNA transcription activation. Nat Commun, 12, 2021
6L87	Solution structure of the tandem PWWP-ARID domains of human RBBP1 分子名称: AT-rich interactive domain-containing protein 4A 著者 Gong, W.B, Perrett, S, Feng, Y.G. 登録日 2019-11-05 公開日 2021-01-06 最終更新日 2024-05-15 実験手法 SOLUTION NMR 主引用文献 Structural insight into chromatin recognition by multiple domains of the tumor suppressor RBBP1. J.Mol.Biol., 2021
7K7T	Crystal structure of human MORC4 ATPase-CW in complex with AMPPNP 分子名称: Isoform 3 of MORC family CW-type zinc finger protein 4, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... 著者 Klein, B.J, Tencer, A.H, Kutateladze, T.G. 登録日 2020-09-24 公開日 2020-11-11 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.94 Å) 主引用文献 Molecular mechanism of the MORC4 ATPase activation. Nat Commun, 11, 2020

<1234567891011>