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7AZB
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BU of 7azb by Molmil
Structure of DDR2 DS domain in complex with VHH
Descriptor: Discoidin domain-containing receptor 2, VHH
Authors:Talagas, A, Nawrotek, A, Arrial, A, Vuillard, L.M, Miallau, L.
Deposit date:2020-11-16
Release date:2020-11-25
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure of DDR2 DS domain in complex with VHH
To Be Published
7S0P
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BU of 7s0p by Molmil
Crystal structure of Porcine Factor VIII C2 Domain Bound to Phosphatidylserine
Descriptor: Coagulation factor VIII, PHOSPHOSERINE
Authors:Peters, S.C, Childers, K.C, Wo, S.W, Brison, C.M, Swanson, C.D, Spiegel, P.C.
Deposit date:2021-08-30
Release date:2021-10-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Stable binding to phosphatidylserine-containing membranes requires conserved arginine residues in tandem C domains of blood coagulation factor VIII.
Front Mol Biosci, 9, 2022
3NNG
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BU of 3nng by Molmil
Crystal structure of the F5/8 type C domain of Q5LFR2_BACFN protein from Bacteroides fragilis. Northeast Structural Genomics Consortium Target BfR258E
Descriptor: CALCIUM ION, uncharacterized protein
Authors:Vorobiev, S, Su, M, Dimaio, F, Baker, D, Seetharaman, J, Janjua, J, Xiao, R, Ciccosanti, C, Foote, E.L, Lee, D, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-06-23
Release date:2010-08-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.177 Å)
Cite:Crystal structure of the F5/8 type C domain of Q5LFR2_BACFN protein from Bacteroides fragilis.
To be Published
5Y4M
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BU of 5y4m by Molmil
Discoidin domain of human CASPR2
Descriptor: 1,2-ETHANEDIOL, human CASPR2 Disc domain
Authors:Liu, H, Xu, F, Zhang, J, Liang, W.
Deposit date:2017-08-04
Release date:2018-08-08
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:Structural mapping of hot spots within human CASPR2 discoidin domain for autoantibody recognition.
J. Autoimmun., 96, 2019
4XZU
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BU of 4xzu by Molmil
Crystal Structure of the Human Factor VIII C2 Domain in Complex with Murine 3E6 Inhibitory Antibody
Descriptor: 3E6 antibody Fab heavy chain, 3E6 antibody Fab light chain, Coagulation factor VIII, ...
Authors:Spiegel, P.C, Wuerth, M.E.
Deposit date:2015-02-05
Release date:2015-12-09
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Structure of the Human Factor VIII C2 Domain in Complex with the 3E6 Inhibitory Antibody.
Sci Rep, 5, 2015
2LS6
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BU of 2ls6 by Molmil
Solution NMR Structure of a Non-canonical galactose-binding CBM32 from Clostridium perfringens
Descriptor: Hyaluronoglucosaminidase
Authors:Grondin, J.M, Chitayat, S, Ficko-Blean, E, Boraston, A.B, Smith, S.P.
Deposit date:2012-04-20
Release date:2013-05-01
Last modified:2024-05-01
Method:SOLUTION NMR
Cite:An unusual mode of galactose recognition by a family 32 carbohydrate-binding module.
J.Mol.Biol., 426, 2014
6OE2
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BU of 6oe2 by Molmil
X-Ray Structure of the C-terminal domain (277-440) of Putative chitobiase from Bacteroides thetaiotaomicron. Northeast Structural Genomics Consortium Target BtR324A. Re-refinement of 3GGL with correct metal Mn replacing Zn. New metal confirmed with PIXE analysis of original sample.
Descriptor: Chitobiase, DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION
Authors:Snell, E.H, Garman, E.F, Lowe, E.D.
Deposit date:2019-03-27
Release date:2019-12-25
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:High-Throughput PIXE as an Essential Quantitative Assay for Accurate Metalloprotein Structural Analysis: Development and Application.
J.Am.Chem.Soc., 142, 2020
8PFE
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BU of 8pfe by Molmil
Crystal Structure of an Hexavariant of the b1 Domain of Human Neuropilin-1 in Complex with the KDKPPR Peptide
Descriptor: ACETATE ION, LYS-ASP-LYS-PRO-PRO-ARG, Neuropilin-1
Authors:Jelsch, C, Favier, F, Didierjean, C.
Deposit date:2023-06-15
Release date:2023-08-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:New Crystal Form of Human Neuropilin-1 b1 Fragment with Six Electrostatic Mutations Complexed with KDKPPR Peptide Ligand.
Molecules, 28, 2023
7RGA
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BU of 7rga by Molmil
Crystal structure of nanoCLAMP3:VHH in complex with MTX
Descriptor: METHOTREXATE, SODIUM ION, nano CLostridial Antibody Mimetic Protein 3 VHH
Authors:Guo, Z, Alexandrov, K.
Deposit date:2021-07-14
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices.
Nat Commun, 12, 2021
9EOU
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BU of 9eou by Molmil
Crystal Structure of the b1b2 domains from Human Neuropilin-1 in complex with a peptide.
Descriptor: Neuropilin-1, Osteopontin
Authors:Caing-Carlsson, R, Duelli, A, Walse, B.
Deposit date:2024-03-15
Release date:2024-06-26
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis.
Pharmacol Res, 205, 2024
9D5D
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BU of 9d5d by Molmil
Crystal Structure of Blood Coagulation Factor VIII C2 Domain Mutant L2251A/L2252A
Descriptor: Factor VIIIa light chain
Authors:Avery, N.G, Childers, K.C, Spiegel, P.C.
Deposit date:2024-08-13
Release date:2024-09-04
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Biophysical characterization of blood coagulation factor VIII binding to lipid nanodiscs that mimic activated platelet surfaces
To Be Published
4LKS
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BU of 4lks by Molmil
Structure of CBM32-3 from a family 31 glycoside hydrolase from Clostridium perfringens in complex with galactose
Descriptor: CALCIUM ION, Glycosyl hydrolase, family 31/fibronectin type III domain protein, ...
Authors:Grondin, J.M, Duan, D, Kirlin, A.C, Furness, H.S, Allingham, J.S, Smith, S.P.
Deposit date:2013-07-08
Release date:2014-12-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens.
Plos One, 12, 2017
4LPL
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BU of 4lpl by Molmil
Structure of CBM32-1 from a family 31 glycoside hydrolase from Clostridium perfringens
Descriptor: CALCIUM ION, Glycosyl hydrolase, family 31/fibronectin type III domain protein, ...
Authors:Grondin, J.M, Duan, D, Heather, F.S, Spencer, C.A, Allingham, J.S, Smith, S.P.
Deposit date:2013-07-16
Release date:2014-07-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Diverse modes of galacto-specific carbohydrate recognition by a family 31 glycoside hydrolase from Clostridium perfringens.
Plos One, 12, 2017
2Z4F
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BU of 2z4f by Molmil
Solution structure of the Discoidin Domain of DDR2
Descriptor: Discoidin domain-containing receptor 2
Authors:Ichikawa, O, Osawa, M, Nishida, N, Goshima, N, Nomura, N, Shimada, I.
Deposit date:2007-06-16
Release date:2007-09-04
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural basis of the collagen-binding mode of discoidin domain receptor 2
Embo J., 26, 2007
6FMC
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BU of 6fmc by Molmil
Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure
Descriptor: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1
Authors:Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P.
Deposit date:2018-01-30
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (0.9 Å)
Cite:Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
5N6W
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BU of 5n6w by Molmil
Retinoschisin R141H Mutant
Descriptor: Retinoschisin
Authors:Ramsay, E.P, Collins, R.F, Owens, T.W, Siebert, C.A, Jones, R.P.O, Roseman, A, Wang, T, Baldock, C.
Deposit date:2017-02-16
Release date:2017-04-12
Last modified:2017-08-30
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural analysis of X-linked retinoschisis mutations reveals distinct classes which differentially effect retinoschisin function
Human Molecular Genetics, 25, 2016
5IJR
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BU of 5ijr by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-1 ligand.
Descriptor: DIMETHYL SULFOXIDE, L-HOMOARGININE, Neuropilin-1
Authors:Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
Deposit date:2016-03-02
Release date:2017-03-29
Last modified:2018-07-11
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
6FMF
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BU of 6fmf by Molmil
Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure
Descriptor: (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid
Authors:Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P.
Deposit date:2018-01-31
Release date:2018-10-17
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.811 Å)
Cite:Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61, 2018
5IYY
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BU of 5iyy by Molmil
X-ray structure of neuropilin-1 b1 domain complexed with Arg-4 ligand.
Descriptor: Neuropilin-1, N~2~-[(benzyloxy)carbonyl]-L-arginine
Authors:Fotinou, C, Rana, R, Djordjevic, S, Yelland, T.
Deposit date:2016-03-24
Release date:2017-04-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Architecture and hydration of the arginine-binding site of neuropilin-1.
FEBS J., 285, 2018
4KI5
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BU of 4ki5 by Molmil
Cystal structure of human factor VIII C2 domain in a ternary complex with murine inhbitory antibodies 3E6 and G99
Descriptor: Coagulation factor VIII, MURINE MONOCLONAL 3E6 FAB HEAVY CHAIN, MURINE MONOCLONAL 3E6 FAB LIGHT CHAIN, ...
Authors:Walter, J.D, Meeks, S.L, Healey, J.F, Lollar, P, Spiegel, P.C.
Deposit date:2013-05-01
Release date:2014-01-15
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structure of the factor VIII C2 domain in a ternary complex with 2 inhibitor antibodies reveals classical and nonclassical epitopes.
Blood, 122, 2013
5C7G
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BU of 5c7g by Molmil
Crystal Structure of the b1 Domain of Human Neuropilin-1 in complex with a bicine molecule
Descriptor: BICINE, Neuropilin-1, SODIUM ION
Authors:Didierjean, C, Jelsch, C.
Deposit date:2015-06-24
Release date:2016-07-06
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Design, synthesis and biological evaluation of new peptidomimetic compounds targeting NRP-1 receptor TO BE PUBLISHED
To Be Published
7O1N
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BU of 7o1n by Molmil
Crystal Structure of Human Neuropilin-1 b1 Domain mutant - Y297A
Descriptor: Neuropilin-1
Authors:Djordjevic, S, Chandanani, J, Faleeva, M, Pinotsis, N.
Deposit date:2021-03-29
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Crystal Structure of Human Neuropilin-1 b1 Domain mutant - Y297A
To Be Published
1IQD
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BU of 1iqd by Molmil
Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.
Descriptor: HUMAN FACTOR VIII, HUMAN MONOCLONAL BO2C11 FAB HEAVY CHAIN, HUMAN MONOCLONAL BO2C11 FAB LIGHT CHAIN
Authors:Spiegel Jr, P.C, Jacquemin, M, Saint-Remy, J.M, Stoddard, B.L, Pratt, K.P.
Deposit date:2001-07-21
Release date:2001-08-15
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII.
Blood, 98, 2001
1TVG
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BU of 1tvg by Molmil
X-ray structure of human PP25 gene product, HSPC034. Northeast Structural Genomics Target HR1958.
Descriptor: CALCIUM ION, LOC51668 protein, SAMARIUM (III) ION
Authors:Kuzin, A.P, Vorobiev, S.M, Lee, I, Acton, T.B, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-06-29
Release date:2004-11-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study.
Proteins, 75, 2009
7P5U
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BU of 7p5u by Molmil
Neuropilin-b1 in a complex with a VEGFB-derived peptide
Descriptor: MGC0122, Neuropilin-1
Authors:Fotinou, C, Rhana, R, Yelland, T.
Deposit date:2021-07-14
Release date:2022-07-27
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Neuropilin-b1 in a complex with a VEGFB-derived peptide
To Be Published

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