1IQD

Human Factor VIII C2 Domain complexed to human monoclonal BO2C11 Fab.

Summary for 1IQD
Related1D7P
DescriptorHUMAN MONOCLONAL BO2C11 FAB LIGHT CHAIN, HUMAN MONOCLONAL BO2C11 FAB HEAVY CHAIN, HUMAN FACTOR VIII, ... (4 entities in total)
Functional Keywordsfactor viii, c2 domain, antibody, blood coagulation, inhibitor, bo2c11, immune system-blood clotting complex, immune system/blood clotting
Biological sourceHomo sapiens (human)
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Cellular locationSecreted, extracellular space: P00451
Total number of polymer chains3
Total formula weight63403.13
Authors
Spiegel Jr., P.C.,Jacquemin, M.,Saint-Remy, J.M.,Stoddard, B.L.,Pratt, K.P. (deposition date: 2001-07-21, release date: 2001-08-15, Last modification date: 2011-07-13)
Primary citationJacquemin, M.,Pratt, K.P.,Saint-Remy, J.M.,Spiegel Jr., P.C.,Stoddard, B.L.
Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII.
Blood, 98:13-19, 2001
PubMed: 11418455
DOI: 110.1182/blood.V98.1.13
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation
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PDB entries from 2021-06-16