3CO2
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3CL1
| M. loti cyclic-nucleotide binding domain, cyclic-GMP bound | Descriptor: | CHLORIDE ION, CYCLIC GUANOSINE MONOPHOSPHATE, Mll3241 protein, ... | Authors: | Clayton, G.M, Alteiri, S.L, Thomas, L.R, Morais-Cabral, J.H. | Deposit date: | 2008-03-18 | Release date: | 2008-08-05 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural and Energetic Analysis of Activation by a Cyclic Nucleotide Binding Domain. J.Mol.Biol., 381, 2008
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3MDP
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1U12
| M. loti cyclic nucleotide binding domain mutant | Descriptor: | IODIDE ION, POTASSIUM ION, SULFATE ION, ... | Authors: | Clayton, G.M, Silverman, W.R, Heginbotham, L, Morais-Cabral, J.H. | Deposit date: | 2004-07-14 | Release date: | 2004-11-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural Basis of Ligand Activation in a Cyclic Nucleotide Regulated Potassium Channel Cell(Cambridge,Mass.), 119, 2004
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1VP6
| M.loti ion channel cylic nucleotide binding domain | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, BROMIDE ION, Cyclic-nucleotide binding domain of mesorhizobium loti CNG potassium channel | Authors: | Clayton, G.M, Silverman, W.R, Heginbotham, L, Morais-Cabral, J.H. | Deposit date: | 2004-10-14 | Release date: | 2004-10-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis of ligand activation in a cyclic nucleotide regulated potassium channel. Cell(Cambridge,Mass.), 119, 2004
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6NP6
| Crystal structure of the sensor domain of the transcriptional regulator HcpR from Porphyromonas Gingivalis | Descriptor: | Crp/Fnr family transcriptional regulator, GLYCEROL | Authors: | Musayev, F.N, Belvin, B.R, Escalante, C.R, Turner, J, Scarsdale, J.N, Lewis, J.P. | Deposit date: | 2019-01-17 | Release date: | 2019-06-26 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Nitrosative Stress Sensing in Porphyromonas gingivalis: Structure and Mechanisms of the Heme Binding Transcriptional Regulator HcpR. Acta Crystallogr D Struct Biol, 75, 2019
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1CX4
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1NE6
| Crystal structure of Sp-cAMP binding R1a subunit of cAMP-dependent protein kinase | Descriptor: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain | Authors: | Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S. | Deposit date: | 2002-12-10 | Release date: | 2004-01-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP. Biochemistry, 43, 2004
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4Z07
| Co-crystal structure of the tandem CNB (CNB-A/B) domains of human PKG I beta with cGMP | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, ISOPROPYL ALCOHOL, SULFATE ION, ... | Authors: | Kim, J.J, Reger, A.S, Arold, S.T, Kim, C. | Deposit date: | 2015-03-25 | Release date: | 2016-04-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation. Structure, 24, 2016
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7SSB
| Co-structure of PKG1 regulatory domain with compound 33 | Descriptor: | 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-nitrobenzoic acid, cGMP-dependent protein kinase 1 | Authors: | Fischmann, T.O. | Deposit date: | 2021-11-10 | Release date: | 2022-08-24 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1 alpha. J.Med.Chem., 65, 2022
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4QX5
| Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG agonist design | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, IODIDE ION, cGMP-dependent protein kinase 1 | Authors: | Huang, G.Y, Gerlits, O.O, Blakeley, M.P, Sankaran, B, Kovalevsky, A.Y, Kim, C. | Deposit date: | 2014-07-18 | Release date: | 2014-11-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.318 Å) | Cite: | Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design. Biochemistry, 53, 2014
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4QXK
| Joint X-ray/neutron structure of PKGIbeta in complex with cGMP | Descriptor: | CYCLIC GUANOSINE MONOPHOSPHATE, SODIUM ION, cGMP-dependent protein kinase 1 | Authors: | Kim, C, Gerlits, O, Kovalevsky, A, Huang, G.Y. | Deposit date: | 2014-07-21 | Release date: | 2014-11-12 | Last modified: | 2024-02-28 | Method: | NEUTRON DIFFRACTION (2.2 Å), X-RAY DIFFRACTION | Cite: | Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design. Biochemistry, 53, 2014
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1NE4
| Crystal Structure of Rp-cAMP Binding R1a Subunit of cAMP-dependent Protein Kinase | Descriptor: | 6-(6-AMINO-PURIN-9-YL)-2-THIOXO-TETRAHYDRO-2-FURO[3,2-D][1,3,2]DIOXAPHOSPHININE-2,7-DIOL, cAMP-dependent protein kinase type I-alpha regulatory chain | Authors: | Wu, J, Jones, J.M, Xuong, N.H, Taylor, S.S. | Deposit date: | 2002-12-10 | Release date: | 2004-01-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structures of RIalpha Subunit of Cyclic Adenosine 5'-Monophosphate (cAMP)-Dependent Protein Kinase Complexed with (R(p))-Adenosine 3',5'-Cyclic Monophosphothioate and (S(p))-Adenosine 3',5'-Cyclic Monophosphothioate, the Phosphothioate Analogues of cAMP. Biochemistry, 43, 2004
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6SYG
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2D93
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6BQ8
| Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ... | Authors: | Kim, C, Kovalevsky, A, Gerlits, O. | Deposit date: | 2017-11-27 | Release date: | 2018-03-21 | Last modified: | 2024-04-03 | Method: | NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION | Cite: | Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator. Biochemistry, 57, 2018
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6CPB
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2KXL
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2K0G
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2MHF
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2MNG
| Apo Structure of human HCN4 CNBD solved by NMR | Descriptor: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 | Authors: | Akimoto, M, Zhang, Z, Boulton, S, Selvaratnam, R, VanSchouwen, B, Gloyd, M, Accili, E.A, Lange, O.F, Melacini, G. | Deposit date: | 2014-04-03 | Release date: | 2014-06-04 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. J.Biol.Chem., 289, 2014
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2Z69
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5BV6
| PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with cGMP | Descriptor: | ACETATE ION, CALCIUM ION, GUANOSINE-3',5'-MONOPHOSPHATE, ... | Authors: | Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W. | Deposit date: | 2015-06-04 | Release date: | 2016-01-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J.Biol.Chem., 291, 2016
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2MPF
| Solution structure human HCN2 CNBD in the cAMP-unbound state | Descriptor: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 | Authors: | Saponaro, A, Pauleta, S.R, Cantini, F, Matzapetakis, M, Hammann, C, Banci, L, Thiel, G, Santoro, B, Moroni, A. | Deposit date: | 2014-05-16 | Release date: | 2014-09-03 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function. Proc.Natl.Acad.Sci.USA, 111, 2014
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2N7G
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