4QX5

Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG agonist design

Summary for 4QX5

Entry DOI	10.2210/pdb4qx5/pdb
Descriptor	cGMP-dependent protein kinase 1, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, IODIDE ION, ... (4 entities in total)
Functional Keywords	phosphate binding cassette/cyclic gmp binding domain/pkg, serine/threonine kinase, cyclic gmp, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : Q13976
Total number of polymer chains	1
Total formula weight	19559.29
Authors	Huang, G.Y.,Gerlits, O.O.,Blakeley, M.P.,Sankaran, B.,Kovalevsky, A.Y.,Kim, C. (deposition date: 2014-07-18, release date: 2014-11-12, Last modification date: 2024-02-28)
Primary citation	Huang, G.Y.,Gerlits, O.O.,Blakeley, M.P.,Sankaran, B.,Kovalevsky, A.Y.,Kim, C. Neutron Diffraction Reveals Hydrogen Bonds Critical for cGMP-Selective Activation: Insights for cGMP-Dependent Protein Kinase Agonist Design. Biochemistry, 53:6725-6727, 2014 Cited by PubMed: 25271401 DOI: 10.1021/bi501012v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.318 Å)

Structure validation