4QX5
Neutron diffraction reveals hydrogen bonds critical for cGMP-selective activation: Insights for PKG agonist design
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CMP A 401 |
| Chain | Residue |
| A | ILE264 |
| A | ALA309 |
| A | ARG316 |
| A | THR317 |
| A | ALA318 |
| A | TYR351 |
| A | VAL283 |
| A | ARG285 |
| A | LEU296 |
| A | ARG297 |
| A | PHE305 |
| A | GLY306 |
| A | GLU307 |
| A | LYS308 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 402 |
| Chain | Residue |
| A | ASP334 |
| A | LYS337 |
| A | IOD403 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 403 |
| Chain | Residue |
| A | IOD402 |
| A | IOD411 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 404 |
| Chain | Residue |
| A | GLU226 |
| A | IOD406 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 405 |
| Chain | Residue |
| A | GLN311 |
| A | GLY341 |
| A | SER347 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD A 406 |
| Chain | Residue |
| A | GLU226 |
| A | GLU254 |
| A | SER277 |
| A | IOD404 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 407 |
| Chain | Residue |
| A | TYR262 |
| A | HOH561 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IOD A 408 |
| Chain | Residue |
| A | HOH566 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD A 410 |
| Chain | Residue |
| A | PRO241 |
| A | GLU242 |
| A | GLU243 |
| A | ILE263 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IOD A 411 |
| Chain | Residue |
| A | IOD403 |
| A | HOH531 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IOD A 412 |
| Chain | Residue |
| A | ILE244 |
| A | HIS256 |
| A | TYR257 |
| A | HIS338 |
| A | IOD415 |
| A | HOH509 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IOD A 413 |
| Chain | Residue |
| A | LYS278 |
| A | THR327 |
| A | HOH526 |
| A | HOH559 |
| A | HOH560 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IOD A 414 |
| Chain | Residue |
| A | HIS256 |
| A | TYR257 |
| A | GLY267 |
| A | VAL326 |
| A | HOH521 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE IOD A 415 |
| Chain | Residue |
| A | ILE244 |
| A | TYR257 |
| A | GLU261 |
| A | HIS338 |
| A | IOD412 |
| A | HOH510 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IOD A 417 |
| Chain | Residue |
| A | GLU254 |
| A | HIS256 |
| A | GLU313 |
| A | HOH582 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 418 |
| Chain | Residue |
| A | GLU254 |
| A | HIS256 |
| A | HOH618 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IOD A 419 |
| Chain | Residue |
| A | ASP303 |
| A | TRP304 |
| A | HOH551 |
Functional Information from PROSITE/UniProt
| site_id | PS00888 |
| Number of Residues | 17 |
| Details | CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrQGArGDtFFIIskG |
| Chain | Residue | Details |
| A | ILE263-GLY279 |
| site_id | PS00889 |
| Number of Residues | 18 |
| Details | CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEkALqgedv......RTAnViA |
| Chain | Residue | Details |
| A | PHE305-ALA322 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24239458","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25271401","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4KU7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QXK","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
