6BQ8
Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP
Summary for 6BQ8
Entry DOI | 10.2210/pdb6bq8/pdb |
Descriptor | cGMP-dependent protein kinase 2, 2-(~2~H_2_)amino-8-[(4-chlorophenyl)sulfanyl]-9-[(2S,4aR,6R,7R,7aS)-2-hydroxy-7-(~2~H)hydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl](~2~H)-1,9-dihydro-6H-purin-6-one, STRONTIUM ION, ... (5 entities in total) |
Functional Keywords | protein kinase g, regulatory domain, neutron crystallography, activator, hydrogen bonding, protonation state, signaling protein, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18087.98 |
Authors | Kim, C.,Kovalevsky, A.,Gerlits, O. (deposition date: 2017-11-27, release date: 2018-03-21, Last modification date: 2024-04-03) |
Primary citation | Gerlits, O.,Campbell, J.C.,Blakeley, M.P.,Kim, C.,Kovalevsky, A. Neutron Crystallography Detects Differences in Protein Dynamics: Structure of the PKG II Cyclic Nucleotide Binding Domain in Complex with an Activator. Biochemistry, 57:1833-1837, 2018 Cited by PubMed: 29517905DOI: 10.1021/acs.biochem.8b00010 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.2 Å) X-RAY DIFFRACTION (2 Å) |
Structure validation
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