6BQ8

Joint X-ray/neutron structure of PKG II CNB-B domain in complex with 8-pCPT-cGMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004692	molecular_function	cGMP-dependent protein kinase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue WNU A 501

Chain	Residue
A	GLN335
A	SER367
A	ALA368
A	ILE370
A	ASP412
A	ARG415
A	DOD605
A	DOD609
A	LYS347
A	TYR354
A	PHE355
A	GLY356
A	GLU357
A	LYS358
A	ALA359
A	ARG366

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site_id	AC2
Number of Residues	2
Details	binding site for residue SR A 502

Chain	Residue
A	ASP364
A	DOD637

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site_id	AC3
Number of Residues	2
Details	binding site for residue MPD A 503

Chain	Residue
A	GLN276
A	TYR277

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Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. IIrEGEeGStFFILakG

Chain	Residue	Details
A	ILE313-GLY329

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEkALisddv......RSAnIiA

Chain	Residue	Details
A	PHE355-ALA372

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	130
Details	Region: {"description":"cGMP-binding, high affinity; cAMP-binding, low affinity","evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BV6","evidenceCode":"ECO:0000312"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26769964","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5BV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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