7SSB
Co-structure of PKG1 regulatory domain with compound 33
Summary for 7SSB
Entry DOI | 10.2210/pdb7ssb/pdb |
Descriptor | cGMP-dependent protein kinase 1, 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-nitrobenzoic acid (3 entities in total) |
Functional Keywords | binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent, protein kinase type ii, signaling protein, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31012.27 |
Authors | Fischmann, T.O. (deposition date: 2021-11-10, release date: 2022-08-24, Last modification date: 2023-10-18) |
Primary citation | Mak, V.W.,Patel, A.M.,Yen, R.,Hanisak, J.,Lim, Y.H.,Bao, J.,Zheng, R.,Seganish, W.M.,Yu, Y.,Healy, D.R.,Ogawa, A.,Ren, Z.,Soriano, A.,Ermakov, G.P.,Beaumont, M.,Metwally, E.,Cheng, A.C.,Verras, A.,Fischmann, T.,Zebisch, M.,Silvestre, H.L.,McEwan, P.A.,Barker, J.,Rearden, P.,Greshock, T.J. Optimization and Mechanistic Investigations of Novel Allosteric Activators of PKG1 alpha. J.Med.Chem., 65:10318-10340, 2022 Cited by PubMed: 35878399DOI: 10.1021/acs.jmedchem.1c02109 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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