7SSB
Co-structure of PKG1 regulatory domain with compound 33
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | cGMP-dependent protein kinase 1 | polymer | 268 | 30466.9 | 1 | UniProt (Q13976) Pfam (PF00027) In PDB | Homo sapiens (Human) | cGK 1,cGK1,cGMP-dependent protein kinase I,cGKI |
2 | A | 4-({(2S,3S)-3-[(1S)-1-(3,5-dichlorophenyl)-2-hydroxyethoxy]-2-phenylpiperidin-1-yl}methyl)-3-nitrobenzoic acid | non-polymer | 545.4 | 1 | Chemie (B4I) | |||
3 | water | water | 18.0 | 155 | Chemie (HOH) |
Sequence modifications
A: 93 - 343 (UniProt: Q13976)
PDB | External Database | Details |
---|---|---|
Met 76 | - | initiating methionine |
Ala 77 | - | expression tag |
His 78 | - | expression tag |
His 79 | - | expression tag |
His 80 | - | expression tag |
His 81 | - | expression tag |
His 82 | - | expression tag |
His 83 | - | expression tag |
His 84 | - | expression tag |
His 85 | - | expression tag |
Glu 86 | - | expression tag |
Asn 87 | - | expression tag |
Leu 88 | - | expression tag |
Tyr 89 | - | expression tag |
Phe 90 | - | expression tag |
Gln 91 | - | expression tag |
Ser 92 | - | expression tag |
Ser 218 | Arg 203 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 30466.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 545.4 | |
All* | Total formula weight | 31012.3 |