2MNG
Apo Structure of human HCN4 CNBD solved by NMR
Summary for 2MNG
| Entry DOI | 10.2210/pdb2mng/pdb |
| NMR Information | BMRB: 19891 |
| Descriptor | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (1 entity in total) |
| Functional Keywords | cyclic amp binding domain, cs-rosetta, transport protein |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane ; Multi- pass membrane protein : Q9Y3Q4 |
| Total number of polymer chains | 1 |
| Total formula weight | 14985.24 |
| Authors | Akimoto, M.,Zhang, Z.,Boulton, S.,Selvaratnam, R.,VanSchouwen, B.,Gloyd, M.,Accili, E.A.,Lange, O.F.,Melacini, G. (deposition date: 2014-04-03, release date: 2014-06-04, Last modification date: 2015-02-11) |
| Primary citation | Akimoto, M.,Zhang, Z.,Boulton, S.,Selvaratnam, R.,VanSchouwen, B.,Gloyd, M.,Accili, E.A.,Lange, O.F.,Melacini, G. A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP. J.Biol.Chem., 289:22205-22220, 2014 Cited by PubMed: 24878962DOI: 10.1074/jbc.M114.572164 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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