Loading
PDBj
メニューPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

新型コロナウイルスの構造情報

このページの他言語版もあります: English简体中文繁體中文한국어
コロナウイルス
コロナウイルス, 2020. David S. Goodsell@RCSB PDB による原画を修正

最近、新型コロナウイルス感染症(Novel Coronavirus disease 2019: COVID-19)の拡大が世界中で深刻な問題となっています。早急にこの新型ウイルス(Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2)を理解し有効な薬を開発するため,関連するタンパク質の構造研究は既に始まっています。そして,解明された構造はPDBに登録されていっています。PDBjでは利用者の利便を図るため,新型コロナウイルス特集ページを作成しました。新たなエントリーが毎週水曜日の週次更新で公開されると、同時にこのページにも追加されます。

またこのウイルスのタンパク質に関する解説記事を以下の「今月の分子」ページに掲載しています。

「全エントリー」のタブでは,同じ著者によるグループ登録のエントリーも全て区別し,すべてのPDB IDを省略せず表示しています。 「代表構造」タブには最も分解能の高い代表構造のみを表示しており,アミノ酸配列が100%同じPDBエントリーはリガンドが異なるものも含め除外してあります。 「最新のエントリー」のタブは,今週公開された最も新しいエントリーです。


作成日: 2020-09-03 (最終更新日: more than 1 year ago)2022-09-02
7JX3
DownloadVisualize
BU of 7jx3 by Molmil
Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab domain of monoclonal antibody S2H14, Heavy chain of Fab domain of monoclonal antibody S304, ...
著者Snell, G, Czudnochowski, N, Rosen, L.E, Nix, J.C, Corti, D, Veesler, D, Park, Y.J, Walls, A.C, Tortorici, M.A, Cameroni, E, Pinto, D, Beltramello, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
登録日2020-08-26
公開日2020-10-14
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Cell, 183, 2020
7K5I
DownloadVisualize
BU of 7k5i by Molmil
SARS-COV-2 nsp1 in complex with human 40S ribosome
分子名称: 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ...
著者Wang, L, Shi, M, Wu, H.
登録日2020-09-16
公開日2020-10-14
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献SARS-CoV-2 Nsp1 suppresses host but not viral translation through a bipartite mechanism.
Biorxiv, 2020
7KAG
DownloadVisualize
BU of 7kag by Molmil
Crystal structure of the ubiquitin-like domain 1 (Ubl1) of Nsp3 from SARS-CoV-2
分子名称: 1,2-ETHANEDIOL, Non-structural protein 3, SULFATE ION
著者Stogios, P.J, Skarina, T, Chang, C, Kim, Y, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2020-09-30
公開日2020-10-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.21 Å)
主引用文献Crystal structure of the ubiquitin-like domain 1 (Ubl1) of Nsp3 from SARS-CoV-2
To Be Published
7A29
DownloadVisualize
BU of 7a29 by Molmil
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23) 2-up conformation
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neutralising sybody (Sb23), ...
著者Hallberg, B.M, Das, H.
登録日2020-08-16
公開日2020-10-21
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
Nat Commun, 11, 2020
7K8M
DownloadVisualize
BU of 7k8m by Molmil
Structure of the SARS-CoV-2 receptor binding domain in complex with the human neutralizing antibody Fab fragment, C102
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C102 Fab Heavy Chain, C102 Fab Light Chain, ...
著者Jette, C.A, Barnes, C.O, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K8S
DownloadVisualize
BU of 7k8s by Molmil
Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C002 (state 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C002 Fab Heavy Chain, ...
著者Barnes, C.O, Malyutin, A.G, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K8U
DownloadVisualize
BU of 7k8u by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C104
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C104 Fab Heavy Chain, ...
著者Barnes, C.O, Malyutin, A.G, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K8V
DownloadVisualize
BU of 7k8v by Molmil
Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C110
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C110 Fab Heavy Chain, ...
著者Dam, K.A, Barnes, C.O, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K8W
DownloadVisualize
BU of 7k8w by Molmil
Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C119
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C119 Fab Heavy Chain, ...
著者Sharaf, N.G, Barnes, C.O, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K8X
DownloadVisualize
BU of 7k8x by Molmil
Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C121 (State 1)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C121 Fab Heavy chain, C121 Fab Light chain, ...
著者Abernathy, M.E, Barnes, C.O, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K8Z
DownloadVisualize
BU of 7k8z by Molmil
Structure of the SARS-CoV-2 S 2P trimer in complex with the human neutralizing antibody Fab fragment, C135
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C135 Fab Heavy Chain, ...
著者Barnes, C.O, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K90
DownloadVisualize
BU of 7k90 by Molmil
Structure of the SARS-CoV-2 S 6P trimer in complex with the human neutralizing antibody Fab fragment, C144
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, C144 Fab Heavy Chain, C144 Fab Light Chain, ...
著者Barnes, C.O, Esswein, S.R, Bjorkman, P.J.
登録日2020-09-27
公開日2020-10-21
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (3.24 Å)
主引用文献SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies.
Nature, 588, 2020
7K9P
DownloadVisualize
BU of 7k9p by Molmil
Room temperature structure of NSP15 Endoribonuclease from SARS CoV-2 solved using SFX.
分子名称: CITRIC ACID, Uridylate-specific endoribonuclease
著者Botha, S, Jernigan, R, Chen, J, Coleman, M.A, Frank, M, Grant, T.D, Hansen, D.T, Ketawala, G, Logeswaran, D, Martin-Garcia, J, Nagaratnam, N, Raj, A.L.L.X, Shelby, M, Yang, J.-H, Yung, M.C, Fromme, P.
登録日2020-09-29
公開日2020-10-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser.
Structure, 2022
7KDT
DownloadVisualize
BU of 7kdt by Molmil
Human Tom70 in complex with SARS CoV2 Orf9b
分子名称: Mitochondrial import receptor subunit TOM70, ORF9b protein
著者QCRG Structural Biology Consortium
登録日2020-10-09
公開日2020-10-21
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science, 370, 2020
7ACT
DownloadVisualize
BU of 7act by Molmil
The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 10mer ssRNA
分子名称: Nucleoprotein, ssRNA
著者Veverka, V.
登録日2020-09-11
公開日2020-10-28
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
Plos Pathog., 16, 2020
7JJC
DownloadVisualize
BU of 7jjc by Molmil
Crystal structure of neuropilin-1 b1 domain in complex with SARS-CoV-2 S1 C-end rule (CendR) peptide
分子名称: DI(HYDROXYETHYL)ETHER, GLYCEROL, Neuropilin-1, ...
著者Chen, K.-E, Collins, B.M.
登録日2020-07-25
公開日2020-10-28
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.36 Å)
主引用文献Neuropilin-1 is a host factor for SARS-CoV-2 infection.
Science, 370, 2020
7K9Z
DownloadVisualize
BU of 7k9z by Molmil
Crystal structure of SARS-CoV-2 receptor binding domain in complex with the Fab fragments of neutralizing antibodies 298 and 52
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 298 Fab Heavy Chain, 298 Fab Light Chain, ...
著者Newton, J.C, Kucharska, I, Rujas, E, Cui, H, Julien, J.P.
登録日2020-09-29
公開日2020-10-28
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.
Nat Commun, 12, 2021
7KFI
DownloadVisualize
BU of 7kfi by Molmil
SARS-CoV-2 Main protease immature form - apo structure
分子名称: 3C-like proteinase, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE
著者Noske, G.D, Nakamura, A.M, Gawriljuk, V.O, Lima, G.M.A, Zeri, A.C.M, Nascimento, A.F.Z, Oliva, G, Godoy, A.S.
登録日2020-10-14
公開日2020-10-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Crystallographic Snapshot of SARS-CoV-2 Main Protease Maturation Process.
J.Mol.Biol., 433, 2021
7KG3
DownloadVisualize
BU of 7kg3 by Molmil
Crystal structure of CoV-2 Nsp3 Macrodomain
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MALONATE ION, ...
著者Arvai, A, Brosey, C.A, Link, T, Jones, D.E, Ahmed, Z, Tainer, J.A.
登録日2020-10-15
公開日2020-10-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors.
Prog.Biophys.Mol.Biol., 163, 2021
7A4N
DownloadVisualize
BU of 7a4n by Molmil
Cryo-EM structure of a prefusion stabilized SARS-CoV-2 Spike (D614N, R682S, R685G, A892P, A942P and V987P)(S-closed trimer)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin
著者Rutten, L, Renault, L.L.R, Juraszek, J, Langedijk, J.P.M.
登録日2020-08-20
公開日2020-11-04
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (2.75 Å)
主引用文献Stabilizing the closed SARS-CoV-2 spike trimer.
Nat Commun, 12, 2021
7ACS
DownloadVisualize
BU of 7acs by Molmil
The SARS-CoV-2 nucleocapsid phosphoprotein N-terminal domain in complex with 7mer dsRNA
分子名称: Nucleoprotein, RNA (5'-R(P*CP*AP*CP*UP*GP*AP*C)-3'), RNA (5'-R(P*GP*UP*CP*AP*GP*UP*G)-3')
著者Veverka, V.
登録日2020-09-11
公開日2020-11-04
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Structural basis of RNA recognition by the SARS-CoV-2 nucleocapsid phosphoprotein.
Plos Pathog., 16, 2020
7CXM
DownloadVisualize
BU of 7cxm by Molmil
Architecture of a SARS-CoV-2 mini replication and transcription complex
分子名称: Helicase, Non-structural protein 7, Non-structural protein 8, ...
著者Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z.
登録日2020-09-02
公開日2020-11-04
最終更新日2025-06-18
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Architecture of a SARS-CoV-2 mini replication and transcription complex.
Nat Commun, 11, 2020
7D6H
DownloadVisualize
BU of 7d6h by Molmil
Crystal structure of the SARS-CoV-2 papain-like protease (PLPro) C112S mutant
分子名称: PHOSPHATE ION, Papain-like protease, ZINC ION
著者Liu, J, Wang, Y, Pan, L.
登録日2020-09-30
公開日2020-11-04
最終更新日2024-09-18
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2.
Cell Chem Biol, 28, 2021
7KDG
DownloadVisualize
BU of 7kdg by Molmil
SARS-CoV-2 RBD down Spike Protein Trimer without the P986-P987 stabilizing mutations (S-GSAS)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2020-10-08
公開日2020-11-04
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.01 Å)
主引用文献D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Cell Rep, 34, 2021
7KDI
DownloadVisualize
BU of 7kdi by Molmil
SARS-CoV-2 D614G 3 RBD down Spike Protein Trimer fully cleaved by furin without the P986-P987 stabilizing mutations (S-RRAR-D614G)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Gobeil, S, Acharya, P.
登録日2020-10-08
公開日2020-11-04
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献D614G Mutation Alters SARS-CoV-2 Spike Conformation and Enhances Protease Cleavage at the S1/S2 Junction.
Cell Rep, 34, 2021

238582

件を2025-07-09に公開中

PDB statisticsPDBj update infoContact PDBjnumon