7JX3

Mapping neutralizing and immunodominant sites on the SARS-CoV-2 spike receptor-binding domain by structure-guided high-resolution serology

Summary for 7JX3

• Entry DOI: 10.2210/pdb7jx3/pdb
• Descriptor: Light chain of Fab domain of monoclonal antibody S309, Heavy chain of Fab domain of monoclonal antibody S309, Light chain of Fab domain of monoclonal antibody S2H14, ... (9 entities in total)
• Functional Keywords: covid-19, sars-cov-2, neutralizing monoclonal antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 165433.84

Authors

Snell, G.,Czudnochowski, N.,Rosen, L.E.,Nix, J.C.,Corti, D.,Veesler, D.,Park, Y.J.,Walls, A.C.,Tortorici, M.A.,Cameroni, E.,Pinto, D.,Beltramello, M.,Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2020-08-26, release date: 2020-10-14, Last modification date: 2023-10-18)

• Primary citation: Piccoli, L.,Park, Y.J.,Tortorici, M.A.,Czudnochowski, N.,Walls, A.C.,Beltramello, M.,Silacci-Fregni, C.,Pinto, D.,Rosen, L.E.,Bowen, J.E.,Acton, O.J.,Jaconi, S.,Guarino, B.,Minola, A.,Zatta, F.,Sprugasci, N.,Bassi, J.,Peter, A.,De Marco, A.,Nix, J.C.,Mele, F.,Jovic, S.,Rodriguez, B.F.,Gupta, S.V.,Jin, F.,Piumatti, G.,Lo Presti, G.,Pellanda, A.F.,Biggiogero, M.,Tarkowski, M.,Pizzuto, M.S.,Cameroni, E.,Havenar-Daughton, C.,Smithey, M.,Hong, D.,Lepori, V.,Albanese, E.,Ceschi, A.,Bernasconi, E.,Elzi, L.,Ferrari, P.,Garzoni, C.,Riva, A.,Snell, G.,Sallusto, F.,Fink, K.,Virgin, H.W.,Lanzavecchia, A.,Corti, D.,Veesler, D.; Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.; Cell, 183:1024-1042.e21, 2020; PubMed: 32991844; DOI: 10.1016/j.cell.2020.09.037

Experimental method

X-RAY DIFFRACTION (2.65 Å)