Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help

COVID-19 featured content

This page is also available in: 日本語简体中文繁體中文한국어
coronavirus
Coronavirus, 2020. Modified from the original illustration by David S. Goodsell@RCSB PDB

The recent outbreak of the Novel Coronavirus disease (COVID-19) is a serious threat to people all over the world. In order to understand and develop an effective drug against this virus (Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2), structural work on the related proteins has already started and the resultant entries are accumulating in the PDB. PDBj provides a portal page for the COVID-19 related entries for our users. New entries will be added simultaneously with the public release from the wwPDB.

An explanation article covering one of the proteins of this virus is available on the "Molecules of the Month" page below:

The tab "All entries" contains all PDB IDs, in case you want to check all independent entries, including group depositions by the same authors. The "Repr. entries" tab contains only representative PDB entries with the highest resolution, excluding duplicate entries with 100% amino acid sequence identitiy, even if they contain a different ligand. Finally, the "Latest entries" tab contains the latest entries released this week.


Created: 2020-10-28 (last edited: more than 1 year ago)2022-09-02
8CMF
DownloadVisualize
BU of 8cmf by Molmil
Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 nsp3 epitope (orf1ab)1350-1364
Descriptor: 1,2-ETHANEDIOL, HLA class II histocompatibility antigen, DR alpha chain, ...
Authors:MacLachlan, B.J, Mason, G.H, Sourfield, D.O, Godkin, A.J, Rizkallah, P.J.
Deposit date:2023-02-19
Release date:2023-07-26
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity.
Cell Rep, 42, 2023
8CMG
DownloadVisualize
BU of 8cmg by Molmil
Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 nsp14 peptide (orf1ab)6420-6434
Descriptor: 1,2-ETHANEDIOL, HLA class II histocompatibility antigen, DR alpha chain, ...
Authors:MacLachlan, B.J, Mason, G.H, Sourfield, D.O, Godkin, A.J, Rizkallah, P.J.
Deposit date:2023-02-19
Release date:2023-07-26
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity.
Cell Rep, 42, 2023
8CMH
DownloadVisualize
BU of 8cmh by Molmil
Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Omicron (BA.1) Spike peptide S486-505
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-ETHANETHIOL, HLA class II histocompatibility antigen, ...
Authors:MacLachlan, B.J, Mason, G.H, Sourfield, D.O, Godkin, A.J, Rizkallah, P.J.
Deposit date:2023-02-19
Release date:2023-07-26
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity.
Cell Rep, 42, 2023
8CMI
DownloadVisualize
BU of 8cmi by Molmil
Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Omicron (BA.1) Spike peptide S761-775
Descriptor: 1,2-ETHANEDIOL, HLA class II histocompatibility antigen, DR alpha chain, ...
Authors:MacLachlan, B.J, Mason, G.H, Sourfield, D.O, Godkin, A.J, Rizkallah, P.J.
Deposit date:2023-02-19
Release date:2023-07-26
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity.
Cell Rep, 42, 2023
8FRJ
DownloadVisualize
BU of 8frj by Molmil
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946
Descriptor: 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Transcription factor ETV6,Guanine-N7 methyltransferase nsp14 chimera, ZINC ION
Authors:Kottur, J, Aggarwal, A.K.
Deposit date:2023-01-07
Release date:2023-07-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
Plos Pathog., 19, 2023
8FRK
DownloadVisualize
BU of 8frk by Molmil
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC8158
Descriptor: 5'-S-(4-{[(4'-chloro[1,1'-biphenyl]-3-yl)methyl]amino}butyl)-5'-thioadenosine, ETHANOL, POTASSIUM ION, ...
Authors:Kottur, J, Aggarwal, A.K.
Deposit date:2023-01-07
Release date:2023-07-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
Plos Pathog., 19, 2023
7WQ8
DownloadVisualize
BU of 7wq8 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with Z-DEVD-FMK
Descriptor: 3C-like proteinase, Z-DEVD-FMK
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-24
Release date:2023-08-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of SARS-CoV-2 main protease in complex with Z-DEVD-FMK
To Be Published
7WQ9
DownloadVisualize
BU of 7wq9 by Molmil
Crystal structure of SARS-CoV-2 main protease in complex with Z-IETD-FMK
Descriptor: 3C-like proteinase, Z-IETD-FMK
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-25
Release date:2023-08-02
Method:X-RAY DIFFRACTION (2.054 Å)
Cite:Crystal structure of SARS-CoV-2 main protease in complex with Z-IETD-FMK
To Be Published
7WQB
DownloadVisualize
BU of 7wqb by Molmil
SARS-CoV-2 main protease mutant (P168A) in complex with MG-132
Descriptor: 3C-like proteinase nsp5, MAGNESIUM ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-25
Release date:2023-08-02
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:SARS-CoV-2 main protease mutant (P168A) in complex with MG-132
To Be Published
7WQK
DownloadVisualize
BU of 7wqk by Molmil
wild-type SARS-CoV-2 main protease in complex with MG-132
Descriptor: 3C-like proteinase, MAGNESIUM ION, N-[(benzyloxy)carbonyl]-L-leucyl-N-[(2S)-1-hydroxy-4-methylpentan-2-yl]-L-leucinamide
Authors:Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chen, Y.
Deposit date:2022-01-25
Release date:2023-08-02
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:wild-type SARS-CoV-2 main protease in complex with MG-132
To Be Published
8DPZ
DownloadVisualize
BU of 8dpz by Molmil
Local refinement of SARS-CoV-2 vaccine induced antibody DH1338 bound to SARS-CoV-2 HexaPro RBD Spike ectodomain
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1338 Fab Heavy Chain, DH1338 Fab Light Chain, ...
Authors:Stalls, V, May, A.J, Acharya, P.
Deposit date:2022-07-18
Release date:2023-08-02
Last modified:2025-05-21
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Local refinement of SARS-CoV-2 vaccine induced antibody Ab026500 bound to SARS-CoV-2 HexaPro RBD Spike ectodomain
To Be Published
8DTK
DownloadVisualize
BU of 8dtk by Molmil
Structure of RBD directed antibody DH1047 in complex with SARS-CoV-2 spike: Local refinement of RBD-Fab interace
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DH1047 Fab Heavy Chain, DH1047 Fab Light Chain, ...
Authors:May, A.J, Manne, K, Acharya, P.
Deposit date:2022-07-25
Release date:2023-08-02
Last modified:2025-05-28
Method:ELECTRON MICROSCOPY (3.77 Å)
Cite:Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates.
Biorxiv, 2023
8SPH
DownloadVisualize
BU of 8sph by Molmil
Crystal structure of chimeric omicron RBD (strain XBB.1) complexed with human ACE2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, W, Shi, K, Aihara, H, Li, F.
Deposit date:2023-05-03
Release date:2023-08-02
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Structural evolution of SARS-CoV-2 omicron in human receptor recognition.
J.Virol., 97, 2023
8SPI
DownloadVisualize
BU of 8spi by Molmil
Crystal structure of chimeric omicron RBD (strain XBB.1.5) complexed with human ACE2
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Zhang, W, Shi, K, Aihara, H, Li, F.
Deposit date:2023-05-03
Release date:2023-08-02
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (3.06 Å)
Cite:Structural evolution of SARS-CoV-2 omicron in human receptor recognition.
J.Virol., 97, 2023
7Y20
DownloadVisualize
BU of 7y20 by Molmil
S-ECD (Omicron BA.3) in complex with two PD of ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H.
Deposit date:2022-06-09
Release date:2023-08-09
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants.
Viruses, 15, 2023
7Y21
DownloadVisualize
BU of 7y21 by Molmil
S-ECD (Omicron BA.5) in complex with PD of ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ...
Authors:Li, Y.N, Shen, Y.P, Zhang, Y.Y, Yan, R.H.
Deposit date:2022-06-09
Release date:2023-08-09
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structural Basis for the Enhanced Infectivity and Immune Evasion of Omicron Subvariants.
Viruses, 15, 2023
7YBH
DownloadVisualize
BU of 7ybh by Molmil
SARS-CoV-2 lambda variant spike
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Wang, X, Fu, W.
Deposit date:2022-06-29
Release date:2023-08-09
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants.
Virol Sin, 37, 2022
7YBL
DownloadVisualize
BU of 7ybl by Molmil
SARS-CoV-2 B.1.620 variant spike (close state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, X, Fu, W.
Deposit date:2022-06-29
Release date:2023-08-09
Last modified:2025-07-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants.
Virol Sin, 37, 2022
7YBM
DownloadVisualize
BU of 7ybm by Molmil
SARS-CoV-2 C.1.2 variant spike (Close state)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, X, Fu, W.
Deposit date:2022-06-29
Release date:2023-08-09
Last modified:2025-06-25
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants.
Virol Sin, 37, 2022
8FIV
DownloadVisualize
BU of 8fiv by Molmil
Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor Jun10541R
Descriptor: (3Z)-N-([1,1'-biphenyl]-4-yl)-3-imino-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]propanamide, 3C-like proteinase nsp5
Authors:Sacco, M, Wang, J, Chen, Y.
Deposit date:2022-12-16
Release date:2023-08-09
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Exploring diverse reactive warheads for the design of SARS-CoV-2 main protease inhibitors.
Eur.J.Med.Chem., 259, 2023
8FIW
DownloadVisualize
BU of 8fiw by Molmil
Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor Jun10221
Descriptor: 3C-like proteinase nsp5, N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]prop-2-enamide, N-([1,1'-biphenyl]-4-yl)-N-[(1S)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]prop-2-enamide
Authors:Sacco, M, Wang, J, Chen, Y.
Deposit date:2022-12-16
Release date:2023-08-09
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Exploring diverse reactive warheads for the design of SARS-CoV-2 main protease inhibitors.
Eur.J.Med.Chem., 259, 2023
8TBE
DownloadVisualize
BU of 8tbe by Molmil
Co-crystal structure of SARS-CoV-2 Mpro with Pomotrelvir
Descriptor: 3C-like proteinase nsp5, Pomotrelvir bound form
Authors:Olland, A, Fontano, E, White, A.
Deposit date:2023-06-28
Release date:2023-08-09
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Evaluation of in vitro antiviral activity of SARS-CoV-2 M pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions.
Antimicrob.Agents Chemother., 67, 2023
8HR2
DownloadVisualize
BU of 8hr2 by Molmil
Ternary Crystal Complex Structure of RBD with NB1B5 and NB1C6
Descriptor: NB1B5, NB1C6, Spike protein S1
Authors:Sun, Z.
Deposit date:2022-12-14
Release date:2023-08-16
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure basis of two nanobodies neutralizing SARS-CoV-2 Omicron variant by targeting ultra-conservative epitopes.
J.Struct.Biol., 215, 2023
8I30
DownloadVisualize
BU of 8i30 by Molmil
Crystal structure of the SARS-CoV-2 main protease in complex with 32j
Descriptor: (2~{R})-1-[4,4-bis(fluoranyl)cyclohexyl]carbonyl-4,4-bis(fluoranyl)-~{N}-[(2~{R},3~{S})-3-oxidanyl-4-oxidanylidene-1-phenyl-4-(pyridin-2-ylmethylamino)butan-2-yl]pyrrolidine-2-carboxamide, 3C-like proteinase nsp5, CHLORIDE ION
Authors:Zeng, R, Huang, C, Xie, L.W, Wang, K, Liu, Y.Z, Yang, S.Y, Lei, J.
Deposit date:2023-01-16
Release date:2023-08-16
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery and structure-activity relationship studies of novel alpha-ketoamide derivatives targeting the SARS-CoV-2 main protease.
Eur.J.Med.Chem., 259, 2023
8IV4
DownloadVisualize
BU of 8iv4 by Molmil
Cryo-EM structure of SARS-CoV-2 spike protein in complex with double nAbs 8H12 and 3E2 (local refinement)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, heavy chain of 3E2, ...
Authors:Sun, H, Jiang, Y, Zheng, Q, Li, S, Xia, N.
Deposit date:2023-03-26
Release date:2023-08-16
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD.
Protein Cell, 15, 2024

238582

PDB entries from 2025-07-09

PDB statisticsPDBj update infoContact PDBjnumon