8FRJ

Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946

Summary for 8FRJ

Entry DOI	10.2210/pdb8frj/pdb
Descriptor	Transcription factor ETV6,Guanine-N7 methyltransferase nsp14 chimera, ZINC ION, 5-bromo-7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, ... (4 entities in total)
Functional Keywords	n7-guanine methyl transferase, sars-cov-2, nsp14, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 More
Total number of polymer chains	1
Total formula weight	36123.24
Authors	Kottur, J.,Aggarwal, A.K. (deposition date: 2023-01-07, release date: 2023-07-26, Last modification date: 2023-09-27)
Primary citation	Kottur, J.,White, K.M.,Rodriguez, M.L.,Rechkoblit, O.,Quintana-Feliciano, R.,Nayar, A.,Garcia-Sastre, A.,Aggarwal, A.K. Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals. Plos Pathog., 19:e1011546-e1011546, 2023 Cited by PubMed: 37523415 DOI: 10.1371/journal.ppat.1011546 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.57 Å)

Structure validation