8FRJ

Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC0946

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004532	molecular_function	RNA exonuclease activity
A	0008168	molecular_function	methyltransferase activity
A	0043565	molecular_function	sequence-specific DNA binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Breakpoint for translocation to form ETV6-MDS2 in MDS

Chain	Residue	Details
A	LEU9

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Breakpoint for translocation to form PAX5-ETV6

Chain	Residue	Details
A	ARG10

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01299

Chain	Residue	Details
A	ASP331

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:36546776

Chain	Residue	Details
A	CYS452
A	CYS477
A	CYS484
A	HIS487

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