8TBE

Co-crystal structure of SARS-CoV-2 Mpro with Pomotrelvir

Summary for 8TBE

Entry DOI	10.2210/pdb8tbe/pdb
Descriptor	3C-like proteinase nsp5, Pomotrelvir bound form (3 entities in total)
Functional Keywords	main protease, viral protein, 3cl protease
Biological source	Severe acute respiratory syndrome coronavirus 2
Total number of polymer chains	2
Total formula weight	68567.00
Authors	Olland, A.,Fontano, E.,White, A. (deposition date: 2023-06-28, release date: 2023-08-09, Last modification date: 2023-11-22)
Primary citation	Tong, X.,Keung, W.,Arnold, L.D.,Stevens, L.J.,Pruijssers, A.J.,Kook, S.,Lopatin, U.,Denison, M.,Kwong, A.D. Evaluation of in vitro antiviral activity of SARS-CoV-2 M pro inhibitor pomotrelvir and cross-resistance to nirmatrelvir resistance substitutions. Antimicrob.Agents Chemother., 67:e0084023-e0084023, 2023 Cited by PubMed: 37800975 DOI: 10.1128/aac.00840-23 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation