8FRK
Structure of nsp14 N7-MethylTransferase domain fused with TELSAM bound to SGC8158
Summary for 8FRK
Entry DOI | 10.2210/pdb8frk/pdb |
Descriptor | Transcription factor ETV6,Guanine-N7 methyltransferase nsp14 chimera, ZINC ION, ETHANOL, ... (6 entities in total) |
Functional Keywords | n7-guanine methyl transferase, sars-cov-2, nsp14, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 1 |
Total formula weight | 36144.93 |
Authors | Kottur, J.,Aggarwal, A.K. (deposition date: 2023-01-07, release date: 2023-07-26, Last modification date: 2023-09-27) |
Primary citation | Kottur, J.,White, K.M.,Rodriguez, M.L.,Rechkoblit, O.,Quintana-Feliciano, R.,Nayar, A.,Garcia-Sastre, A.,Aggarwal, A.K. Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals. Plos Pathog., 19:e1011546-e1011546, 2023 Cited by PubMed: 37523415DOI: 10.1371/journal.ppat.1011546 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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