7YBM

SARS-CoV-2 C.1.2 variant spike (Close state)

This is a non-PDB format compatible entry.

Summary for 7YBM

• Entry DOI: 10.2210/pdb7ybm/pdb
• EMDB information: 33726
• Descriptor: Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: sars-cov-2, lambda, spike, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV, SARS-CoV-2)
• Total number of polymer chains: 3
• Total formula weight: 446674.92

Authors

Wang, X.,Fu, W. (deposition date: 2022-06-29, release date: 2023-08-09, Last modification date: 2024-11-20)

Primary citation

Xing, X.,Wang, L.,Cui, Z.,Fu, W.,Zheng, T.,Qin, L.,Ge, P.,Qian, A.,Wang, N.,Yuan, S.
Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants.
Virol Sin, 37:938-941, 2022

PubMed Abstract: • Deletion of residues 156–157 warps the neighboring beta-sheet and leads NTD and RBD to shift. • T859N stabilizes the packing of the 630 loop motif to make RBD standing transition more difficult. • The overall structures of the closed state S complex from different variants resemble each other. • Mutations in FPPR may affect the overall structure of the trimeric spike protein.

PubMed: 36368512
DOI: 10.1016/j.virs.2022.11.003

Experimental method

ELECTRON MICROSCOPY (3.45 Å)