登録情報 データベース : PDB / ID : 2z6w 構造の表示 ダウンロードとリンクタイトル Crystal structure of human cyclophilin D in complex with cyclosporin A 要素CYCLOSPORIN A PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 詳細キーワード ISOMERASE/IMMUNOSUPPRESSANT / ISOMERASE-IMMUNOSUPPRESSANT COMPLEX / CYCLOPHILIN-CYCLOSPORIN COMPLEX / CYCLOSPORIN A / IMMUNOSUPPRESSANT / CYCLOPHILIN D機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of proton-transporting ATPase activity, rotational mechanism / negative regulation of oxidative phosphorylation uncoupler activity / mitochondrial outer membrane permeabilization involved in programmed cell death / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / skeletal muscle fiber differentiation / mitochondrial permeability transition pore complex / negative regulation of ATP-dependent activity / cellular response to arsenic-containing substance / mitochondrial depolarization / negative regulation of oxidative phosphorylation ... regulation of proton-transporting ATPase activity, rotational mechanism / negative regulation of oxidative phosphorylation uncoupler activity / mitochondrial outer membrane permeabilization involved in programmed cell death / regulation of mitochondrial membrane permeability involved in programmed necrotic cell death / skeletal muscle fiber differentiation / mitochondrial permeability transition pore complex / negative regulation of ATP-dependent activity / cellular response to arsenic-containing substance / mitochondrial depolarization / negative regulation of oxidative phosphorylation / regulation of mitochondrial membrane permeability / cyclosporin A binding / negative regulation of release of cytochrome c from mitochondria / necroptotic process / apoptotic mitochondrial changes / protein peptidyl-prolyl isomerization / negative regulation of intrinsic apoptotic signaling pathway / cellular response to calcium ion / response to ischemia / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / peptide binding / cellular response to hydrogen peroxide / protein folding / mitochondrial inner membrane / mitochondrial matrix / negative regulation of apoptotic process / mitochondrion / membrane / cytoplasm 類似検索 - 分子機能 Cyclophilin-like / Cyclophilin / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily / Beta Barrel / Mainly Beta 類似検索 - ドメイン・相同性 Cyclosporin A / CITRIC ACID / : / Peptidyl-prolyl cis-trans isomerase F, mitochondrial 類似検索 - 構成要素生物種 HOMO SAPIENS (ヒト)TOLYPOCLADIUM INFLATUM (菌類)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 0.96 Å 詳細データ登録者 Kajitani, K. / Fujihashi, M. / Kobayashi, Y. / Shimizu, S. / Tsujimoto, Y. / Miki, K. 引用ジャーナル : Proteins / 年 : 2008タイトル : Crystal Structure of Human Cyclophilin D in Complex with its Inhibitor, Cyclosporin a at 0.96-A Resolution.著者 : Kajitani, K. / Fujihashi, M. / Kobayashi, Y. / Shimizu, S. / Tsujimoto, Y. / Miki, K. 履歴 登録 2007年8月9日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2008年4月29日 Provider : repository / タイプ : Initial release改定 1.1 2011年6月14日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2011年7月27日 Group : Atomic model / Database references ... Atomic model / Database references / Derived calculations / Non-polymer description / Structure summary 改定 1.4 2012年12月12日 Group : Other改定 1.5 2023年11月1日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id 改定 1.6 2023年11月15日 Group : Data collection / Derived calculations / カテゴリ : chem_comp_atom / chem_comp_bond / struct_connItem : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 / _struct_conn.pdbx_leaving_atom_flag
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